Index Catalog // Arch : Northwestern University Institutional Repository

Defining the role of Ikaros as a tumor suppressor and repressor of Notch target gene expression

Description:: Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...
Keyword:: Notch, Ikaros, tumor suppressor, and RBP-J
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Katie L Kathrein
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/01/2018
Date Modified:: 09/01/2018
Date Created:: 2008-02-22
Resource Type:: Dissertation

Molecular mechanisms mediating activation of cytomegalovirus major immediate early enhancer in allogeneic transplantation

Description:: Reactivation of latent human cytomegalovirus is of significant concern in immunocompromised transplant patients. However, the mechanisms controlling reactivation of latent CMV have not been understood. It is likely that reactivation is initiated by induction of IE gene expression. In this thesis, I studied molecular mechanisms leading to transcriptional activation of...
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Soo Jung Kim
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/10/2018
Date Modified:: 05/10/2018
Date Created:: 2006-12-22
Resource Type:: Dissertation

Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

Description:: Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
Keyword:: HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Anne Marie Strohecker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/30/2018
Date Modified:: 07/30/2018
Date Created:: 05-15-2007
Resource Type:: Dissertation

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Description:: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maria Soderberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-03-25
Resource Type:: Dissertation

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Description:: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Achuta K Guddati
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Description:: The actions of luteinizing hormone (LH) to induce ovulation and luteinization of preovulatory follicles are mediated principally by activation of cAMP-dependent protein kinase (PKA) in granulosa cells. PKA activity is targeted to specific cellular locations by A-kinase anchoring proteins (AKAPs). I previously showed that follicle-stimulating hormone (FSH) induces expression of...
Keyword:: cyloskeleton, MAP2, vimentin, ovary, granulosa cell, and luteinizing hormone
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maxfield Patrick Flynn
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/03/2018
Date Modified:: 10/03/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Description:: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
Keyword:: Biochemistry and Chemical
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristel Vercauteren
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
Keyword:: NGF, sympathetic nervous system, and Egr3
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Laurie Christine Eldredge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

Description:: Fusion of biological membranes is dictated by the interaction between specialized membrane proteins and the lipid bilayer. Parainfluenza virus 5 (PIV5) mediates fusion using two surface glycoproteins: the fusion protein (F) and the attachment protein hemagglutinin-neuraminidase (HN). Activation of membrane fusion of PIV5 typically occurs at neutral pH, and involves...
Keyword:: Class I virus fusion, PIV5, fusion protein, and Membrane fusion
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mei Lin Bissonnette
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-11-06
Resource Type:: Dissertation

The Role of TGF-beta Variants in Breast Cancer

Description:: TGF-β has been named the molecular Jekyll and Hyde of cancer due to its ability to both suppress and promote tumor development. Components of the TGF-β signaling pathway are often mutated in cancer to inhibit the tumor suppressor roles of TGF-β. Our lab studies how a 3-alanine deletion in the...
Keyword:: Biology and Genetics
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Diana Susan Rosman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-10-14
Resource Type:: Dissertation

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Defining the role of Ikaros as a tumor suppressor and repressor of Notch target gene expression

Molecular mechanisms mediating activation of cytomegalovirus major immediate early enhancer in allogeneic transplantation

Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

The Role of TGF-beta Variants in Breast Cancer

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