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Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Description:

Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...

Keyword:

[SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1

Subject:

Molecular biology, Bioinformatics, and Neurosciences

Creator:

Goncharoff, Dustin Kenneth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538
Molecular and Computational Studies of TDP-43 and FUS Proteinopathies

Description:

Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...

Keyword:

microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria

Subject:

Molecular biology, Bioinformatics, and Neurosciences

Creator:

McGee, Warren A

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037

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Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Molecular and Computational Studies of TDP-43 and FUS Proteinopathies

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