Heart failure is a growing clinical problem, and inherited cardiomyopathies contribute significantly to heart failure. Among the many genes associated with inherited cardiomyopathies, mutations in FLNC, the gene encoding the cytoskeletal protein filamin C, associate with a range of cardiomyopathy and increased risk for arrhythmia and sudden cardiac death in...
In recent years, motivated by the approaching of quantum limit for classic information science, the development of quantum information science (QIS) has drawn considerable interest from chemists and physicians. Different from classical bits which can only be localized on two different states, quantum bit, which can be simplified as qubit,...
Nilotinib is a highly effective tyrosine kinase inhibitor used to treat Chronic Myeloid Leukemia (CML). While nilotinib successfully treats CML, a common and serious side effect is development of nilotinib-induced arterial disease (NAD) even in patients without pre-existing risk factors. This side effect is not seen with imatinib, a CML...
Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been under-explored, and the properties of vaccine-induced Mtb lipid-specific memory T cells have remained elusive. Mycolic acid (MA), a major lipid component of the...
In the late 2000’s, scientific studies in cultural heritage saw a great advancement in macro X-ray fluorescence (XRF) imaging of paintings. These images are used to generate elemental distribution maps, which aid in identifying chemical elements and paint pig- ments as well as their locations throughout the layers of the...
Objective: To evaluate patient-reported experiences of telehealth and disparities in access, use, and satisfaction with telehealth visits during the COVID-19 pandemic (aim 1), to evaluate prevalence of portal use pre-, peri-, and post-pandemic, among the C3 cohort, and investigate any disparities in use by sociodemographic factors (aim 2), and to...
Heterogenous catalysis is the pillar of chemical production and a crucial aspect for optimization toward a sustainable future. To improve the current design of heterogeneous catalysts of maximal activity and product selectivity, gaining fundamental understanding of the catalytic active sites is crucial. The nature of active sites has been the...
In this thesis, I study the effects of spillovers in all-pay auctions and the effects ofregulating wages and hours on the labor market. In the first chapter, I study a model of
asymmetric all-pay auctions with spillovers. In this model, players compete for a prize, and
the sunk effort players...
Air pollution is a pervasive environmental issue that has significant impacts on human health. Urban areas are particularly susceptible to high levels of air pollution due to concentrated emissions and populations. Urban air pollution has been linked to a range of adverse health effects, including respiratory diseases, cardiovascular diseases,...
Biological systems that perform critical reactions like carbon dioxide reduction, water oxidation, or phosphonate ester hydrolysis consist of many separate components with many different degrees of
freedom. While the functionality of pieces of these systems can be replicated synthetically to some
degree, the integration of synthetic catalysts into an overall...
The main topic of this thesis is generation in derived categories of coherent sheaves on smooth projective varieties. We develop a new approach that allows us to give a new proof of a recent result by Olander that powers of an ample line bundle generate the bounded derived category of...
Equilibrium models of star formation successfully derive the globally-averaged Kennicutt-Schmidt (KS) relation, positing that star formation rates (SFRs) are self- regulated by the turbulence in the interstellar medium (ISM) generated by stellar feedback. However, these models make assumptions that may not be achieved in realistic galaxy systems. Cosmological zoom-in simulations,...
An important tenet in memory research is the dissociation between explicit and implicit memory systems in the brain. Whereas a robust literature exists on the consolidation of memories in the explicit domain, research on implicit memory consolidation is relatively understudied, particularly questions about what is being consolidated and the mechanisms...
On March 11, 1966, Indonesian President Soekarno suddenly transferred executive power to the Army, which has played a role in the Indonesian state and society since the late 1950s. This act replaced Soekarno’s own government with a military dictatorship dubbed the New Order, which lasted for nearly 32 years. Why...
As sound changes advance across large geographic areas, they progress unevenly across populations. The speakers who lead these changes often share macro-social identities, like place or social class affiliations (e.g. Nesbitt 2018; Wagner et al. 2016). But the features undergoing these macro-level sound changes also hold social meanings related to...
The negative early and late health consequences from exposure to artificial sources of radiation are particularly apparent in victims of radiological emergencies who were diagnosed with cancer, radiation pneumonitis, among other conditions. The renaissance of nuclear energy, increased use of ionizing radiation in the medical field, and nuclear threats from...
Polymers occupied nearly every facet of our daily lives, and enhancing their mechanical and fracture properties has long been an important topic in the field of polymer science. Based on the various need in applications, polymers are designed to have a range of characteristics such as tackiness, optical properties, mechanical...
Data for manuscript submission to PLoS ONE entitled:
Prior Uncertainty Impedes Discrete Locomotor Adaptation
Authors:
Jiang, Aojun
Grover, Francis M.
Bucklin, Mary
Deol, Jasjit
Shafer, Anna
Gordon, Keith E.
This data was used to compare the performance of a urine point-of-care assay and interviewer-administered timeline follow-back to the gold-standard for measuring recent and longer-term adherence of pre-exposure prophylaxis (PrEP) in dried blood spots (DBS). This data was used to produce the research findings presented in the peer-reviewed journal cited...
People sometimes gain a sudden idea through insight after being stuck on a problem. Researchers have been studying insight as a crucial component of creative problem-solving in the past decades. However, the role of insight in mathematical problem-solving remains unclear, while mathematics is essential in scientific development and ubiquitous in...