This dissertation explores the extent to which Portuguese theologian, papal penitentiary, bishop, and abbot Andreas de Escobar, O.S.B. (1348-1448) benefited from contemporary trends in manuscript culture and thereby functioned as a late-medieval public intellectual. Recent research suggests that early-fifteenth-century university-trained theology masters used their expertise and authority to intervene into...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive motoneuron loss. Autopsy from thoracic spinal tissues of sALS patients revealed a significant loss of large motoneurons while medium and small motoneurons were relatively unaffected. Using two-photon microscopy, we observed a soma hypertrophy of neonatal motoneurons in mice overexpressing mutant human G93A-superoxide...
Supported metal oxides are an important class of catalysts for chemical synthesis and manufacturing, particularly for selective oxidation reactions. This dissertation seeks to understand broad relationships among families of silica-supported Group 4 and 5 metal oxide catalysts for the synthesis of epoxides with hydrogen peroxide (H2O2) and to further extend...
Organic photovoltaics (OPVs) are an attractive solar energy technology for low-current applications. Herein is described the supramolecular design and methodology to manipulate intermolecular interactions in order to create an active layer in OPVs devices composed of crystalline and amorphous donor-acceptor domains, which has been proposed as the ideal morphology for...
Regeneration is a complex biological phenomenon. Organisms that regenerate must possess robust mechanisms that direct new tissue production of the appropriate size and pattern to allow for correct and functional integration with preexisting tissue structures. Planarians are flatworms capable of regenerating from nearly any injury, making them a powerful system...
Polyurethane (PU) is an important commodity polymer with a broad range of applications. Increasing regulations on isocyanates have prompted investigations into alternative routes to PU. Cyclic carbonate aminolysis leading to polyhydroxyurethane (PHU) is a promising alternative. This dissertation describes the first fundamental investigation of the synthesis and properties of segmented,...
This dissertation provides the first in-depth comparative study in any language of the female figurations made, viewed, and interpreted in the realm of refashioning modern Chinese painting during the war period of Republican China (1930s-1940s) in the Nationalist government-controlled southwestern inner frontier, with projects by Pang Xunqin (1906–85) and Fu...
X-ray reflectivity (XRR) versatile technique that characterize the surface structures. However, due to the lack of phase information of X-ray data, the reconstruction of electron density profile (EDP) from XRR data is an ill-posed inverse problem that requires extra attention. In Chapter 1, several key concepts in XRR data analysis...
In December 1928, Ernst Jünger wrote to his brother Friedrich Georg: “Wir müssen uns […] bemühen, die literarische Tätigkeit als Kriegsmittel zu betrachten.” This project analyzes the result of said activity: viz. text understood as a means of war. That is to say, it does not aim at answering questions...
Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy. Due to the aggressive nature of these tumors and our inability to adequately treat them, only 3-5% of patients survive longer than 3 years post-diagnosis. The standard of care for newly diagnosed GBM is surgical resection followed by...
Classic mechanism design studies the implementation of optimal systems or processes in the presence of multiple selfish and fully rational agents. The theory of mechanism design has been one of the most celebrated advances in the economics discipline, especially with regards to auctions Myerson (1981),Vickrey (1961), Clarke (1971), Groves (1973)....
Musicians have a responsibility to assess and perform new or extant music in order to present a larger body of repertoire to audiences. The purpose of this study is to introduce the euphonium music of the contemporary Belgian composer Frangois Glorieux to the tubaeuphonium community. With numerous works written for...
Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2-11% of children worldwide with no treatments in sight. In my thesis work, I aimed to identify underlying biological mechanisms of the FAE-induced hippocampus-based cognitive deficits that would lead to identify potential treatment targets to reverse the...
Nano-structured mixed ionic and electronic conducting (MIEC) materials have garnered intense interest in electrode development for solid oxide fuel cells due to their high surface areas which allow for effective catalytic activity and low polarization resistances. In particular, composite solid oxide fuel cell (SOFC) cathodes consisting of ionic conducting scaffolds...
Kainate receptors (KARs) are expressed throughout the central and peripheral nervous systems. One of three subfamilies of ionotropic glutamate receptors, KARs are localized both pre- and post-synaptically and exert important modulatory control over neural circuits. This modulatory role in circuit function makes them a potential actor in wide variety of...
Radiation is a ubiquitous health risk. Contemporary populations are exposed to several hundred milliSieverts per person over their lifetimes from both natural and human made sources such as radon, cosmic rays, CT-scans, etc. Risk estimates based on studies of atomic bomb survivors suggest that these exposures induce excess cancer mortality...
Patients born with severe heart defects need regular monitoring of the complex hemodynamics in their heart and vasculature. 4D flow MRI has emerged as the state-of-the-art technique for comprehensively evaluating cardiovascular hemodynamics. This imaging technique allows for the dynamic visualization of 3D blood through the cardiac cycle and the quantification...
With the dual challenges of meeting global energy demand and mitigating anthropogenic climate change, significant effort is being applied to generating power from renewable sources. The dye-sensitized solar cell (DSC) is a photovoltaic technology capable of generating electricity from sunlight, but suffers losses in efficiency due to deleterious electron transfer...
Algebras and their bimodules form a 2-category in which 2-morphisms are certain zero-th Hochschild cohomology groups. When we derive this structure (i.e., use Hochschild cochains instead of HH^0 for 2-morphisms), we find that algebras form a category in dg cocategories. The Hochschild-Kostant-Rosenberg theorem and non-commutative calculus give a rich algebraic...
We studied the nonlocal effects of intraspecific prey competition on the stability of the critical points of the Rosenzweig-MacArthur model and the Holling-Tanner model, respectively, using linear stability analysis. In particular we focused on the study of the stability of the coexistence state influenced by the nonlocality for both models....
Advancements in nanotechnology have led to the production of devices with components with sub-100 nm size scales. Studies have investigated how properties of polymers change when confined to nanoscale dimensions. However, stiffness-confinement studies have reported increases, decreases, and invariance with confinement for different polymer/substrate pairs, making it difficult to obtain...
Scholars have noted that food marketing significantly impacts the lives of children, influencing what foods they request and consume. However, the impact of food marketing on low-income children has only been explored minimally. This project explores both media-based and in-store food marketing to low-income families, along with potential outcomes of...
The development of metal-based probes has provided major benefits to understanding basic biological process and clinical outcomes. Metals offer access to geometries that carbon alone cannot attain, along with valuable magnetic, optical, and binding properties. Metals have proven to be particularly useful in advancing molecular imaging, a field that seeks...
As the title suggests, this dissertation is composed of three major topics. The first two are optimization problems focusing on developing effective solution methodologies, while for the last topic we present a large-scale information retrieval system in the domain of sports. With the algorithms and frameworks developed in this dissertation,...
The genetic code, a set of rules by which mRNA codons are translated into the twenty standard amino acids used in protein synthesis, was once thought to be immutable. As we expanded our understanding of molecular biology more variations in this genetic code have been found across the animal kingdom....
Natural products provide a renewable resource of novel chemical structures with relevance to the pharmaceutical, agricultural and materials industries. Genome sequencing has revealed that these industries currently rely on only a fraction of the number of natural products that exist in nature. Based on the impact that known natural products...
The polypeptide hormone prolactin (PRL) is increasingly recognized as contributing to the development and progression of human breast cancer. This is supported by epidemiologic studies that found women with high levels of serum PRL are at an increased risk for developing breast cancer. Activation of the prolactin receptor (PRLR) by...
Loss of inhibitory control from descending serotonergic (5-HT) fibers deregulates the excitability of spinal motoneurons and interneurons following spinal cord injury (SCI). Exaggerated synaptic activity triggers long-lasting excitatory postsynaptic potentials (long EPSPs) in hyperexcitable motoneurons to ultimately drive muscle spasms at the chronic stage of SCI. Deep dorsal horn (DDH)...
The impacts of many important technologies are limited by the availability of better-performing materials. One factor limiting the ability of engineers to develop better materials is the speed at which they can search through possible formulations and processing schemes. Recently, machine learning algorithms have emerged as a possible route to...
Age-related cognitive deficits are observed in both humans and animals. Yet, the molecular mechanisms underlying these deficits are not yet fully elucidated. In aged animals, a decrease in intrinsic excitability of pyramidal neurons from the CA1 sub-region of hippocampus is believed to contribute to age-related cognitive impairments, but the molecular...
Increasing energy demand due to rapid growth in population and industrialization along with environmental crisis has led to the search for cheap, environmentally friendly, and nontoxic methods for generation of energy. However, most alternative energy sources such as photovoltaic, biofuels, hydraulic power, wind power, and geothermal energy, are characterized by...
This dissertation presents a Nuclear Magnetic Resonance (NMR) study of a novel anisotropic superconductor, HgBa$_{2}$CuO$_{4+\delta}$ (Hg1201) and unconventional strain dependence of the mean free path of silica aerogel. Hg1201 is one of the most structurally simple cuprates known. Therefore, it is an ideal compound in investigation of various phases in...
Dopaminergic neurons in the substantia nigra pars compacta are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors inhibits spike generation, the consequences of GABAB receptor activation are less well...
How can gatekeeping theory in the circulation of cultural objects, including knowledge production, inform the way cultural sociology investigates the role of the producer and the cultural object as “gated” entities? Using the case of producers working under the rubric of “Contemporary African art” to investigate opportunities and restrictions to...
This dissertation explores the renewed historical significance of the (geo)political demand to redraft national constitutions in the Americas. Building on previous work, my dissertation constructs a transnational lens to underline the intersectionality of the social struggles that catalyzed the Venezuelan Constituent Assembly process begun in 1999 and the Ecuadorian experience...
Analytic jurisprudence is the field organized around the “What is law?” question. When most scholars approach the “What is law?” question, they suppose that the goal of such inquiry is to discover, or to accurately represent, the true nature of law. Consequently, these scholars reject the notion that the goal...
FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...
We define multi-indexed Deligne extensions and multi-indexed log-variations of Hodge structures in the category of (filtered) logarithmic D-modules, via the idea of Bernstein– Sato polynomials and Kashiwara–Malgrange filtrations, generalizing the Deligne canonical extensions of flat vector bundles. We also obtain many comparison results with perverse sheaves via the logarithmic de...
The scope of this thesis extends to the study of surface structures and electronic properties in a number of complex oxides. The c(6x2) surface reconstruction on SrTiO3 (001) was solved using a combination of plan view transmission electron microscopy imaging, atomic resolution secondary electron imaging, and density functional theory calculations....
This dissertation explores the relationship between institutions of political participation and environmental protection. What is the relationship and how is it constituted? How are participatory institutions put into motion, and how do they operate? What are the effects of these institutions? Are participatory institutions desirable from an environmental perspective and...
We often criticize others for beliefs that are dogmatic, biased, or wishful. What, exactly, are we criticizing? Many epistemologists accept that such believing is problematic because it is not appropriately responsive to epistemic reasons. But why care about that? Or, to put it another way, why are epistemic norms authoritative...
This work is concerned with the Laudau-Ginzburg $A$-model, or the Fukaya-Seidel category, associated with a Laurent polynomial $f: (\C^*)^n \ o \C$. We use constructible sheaves on a real $n$-dimensional torus to describe the Lagrangian thimbles associated to $f$. Then we discuss the application to Homological Mirror Symmetry for smooth...
Freeze casting is a technique for processing porous materials that has drawn significant attention for its effectiveness in producing a variety of tailorable pore structures for ceramics, metals, and polymers. With freeze casting, pores are generated based on a solidification process where ice crystals act as a sacrificial template which...
This dissertation contains two studies. In Chapter 1, I implement a randomized intervention to measure the effect of reminders for timely payment of credit cards. While I find an 13% reduction in the cost of late payment fees paid, 31% of the users that avoid credit card late payments, incur...
Changing economic activities bring significant cultural, epidemiological, and nutritional transitions. These transitions have important and lifelong effects on the health of populations experiencing them. Infancy represents a critical period when rapid growth and metabolic programming occur, making infants particularly vulnerable to long-lasting biological changes due to such transitions. The objective...
After 9/11 there was a shift in the rhetoric surrounding counter-terrorism. Suddenly, the language of risk, security and prevention was being utilized to justify a new set of global financial regulations headed up by international organizations such as the United Nations, The Financial Action Task Force, and the IMF/World Bank....
Achievement gaps between students from different SES and racial/ethnic backgrounds stubbornly persist despite decades of policy interventions. My dissertation focuses on several unexpected sources of stress and disruption that may be related to the achievement gap: sunlight exposure, a sister’s teen childbearing, and nearby violent crime. I demonstrate that these...
The concept of deportation has become increasingly important in recent years, as states more and more turn to removal as a technique of control over population and territory. But within the field of political theory the concept of deportation has not yet received the attention it deserves. This dissertation helps...
Mobile traffic is expected to grow tenfold by 2019, topping 24 exabytes of monthly traffic and accounting for nearly half of all Internet traffic. This growth is driven by the increasing number of smart phones and tablets, and the data demands of high bandwidth services enabled by next-generation cellular networks...
An important question in religious and theological ethics concerns the human capacity for moral action, but contemporary Christian theological anthropologies largely theorize the human person in terms of the imago Dei, not moral subjectivity. The following study contributes to this challenge an investigation of human moral agency in the theological...
Both chapters of this dissertation relate to the aggregate value of corporations in an economy. In particular, they relate to the ratio of the aggregate total market value of corporations over the replacement cost of their recorded capital. The first chapter introduces a model that can explain why this ratio...
Metal and bimetallic nanoparticles are of interest and are widely used in various applications because of their unique optical, electronic, and catalytic properties, which differ from those of their bulk counterparts. Better understanding of the thermodynamic and kinetic properties of nanoparticles and their underlying growth mechanisms can serve as a...
People today increasingly first meet others in mediated spaces, undergoing impression formation processes where they view information, gain impressions, and make decisions about others. Previous research examines profile information (e.g. name, photo, about me) that people provide about themselves within this process, finding that people try to craft profiles for...
The African trypanosome Trypanosoma brucei is a single-celled eukaryotic protozoan parasite with a single cilium/flagellum. It cycles between its mammalian host (bloodstream cell), in which it scavenges cholesterol, and its tsetse fly host (procyclic cell), in which it both scavenges cholesterol and synthesizes ergosterol. For the first part of the...
"Migration Forms” centers on the place where migration and Morocco meet to tell two stories. One argues for the centrality of migration to the projects of local, contemporary art making and postcolonial nation building, while the other examines the codification, circulation, and contestation through visual form of this North African...
In this dissertation, I discuss the role of neutrino masses and fermion flavor in modern particle physics and present several efforts aimed at exploiting these properties in searches for new physics. In particular, I discuss (1) the effects of neutrino decays on neutrino propagation; (2) the sensitivity of the Deep...
Significant deviations in the glass transition temperature (Tg) of nanoconfined polymer films from the bulk have been studied for over twenty years with the focus on high molecular weight (MW), linear polymers. This thesis explores low MW polymers, which represent an important class of materials widely used as coatings, detergents,...
In March 1977 an exceptionally strong earthquake struck Romania ruled by the communist president and dictator Nicolae Ceauşescu and his regime. The policies and actions implemented and undertaken in the days, weeks, and year that followed were forms of aftershocks. The Ceauşescu regime modeled the 1977 earthquake recovery on previous...
Languages provide expressions that allow its users to indicate their source of information for a given claim, which can have an effect of attenuating how committed they appear to be to the truth of their claims (e.g., ame-ga futteiru-sooda ‘It is raining, I hear’). This linguistic notion has been termed...
Founded in Oakland, California, in 1966 to confront the crisis of anti-black police violence in the Bay Area, the Black Panthers advocated armed struggle against the violences and aggressions of racist American imperialism domestically and internationally. Against interpretations that would deem their image-making to be secondary to their professed political...
The U.S. Department of Education’s Ready To Learn (RTL) initiative funds (a) mass media and related community outreach intended to promote school readiness among all children—especially at-risk populations—, and (b) formative and summative research by third party evaluators (Michael Cohen Group, 2012). Today, the majority of American preschoolers have consumed...
Knot invariants can be defined using Legendrian isotopy invariants of the knot conormal. There are two types of invariants raised in this way: one is the knot contact differential graded algebra together with augmentations associated to this dga, and the other one is the category of simple sheaves microsupported along...
This dissertation comprises three essays on industrial organization. In Chapter 1 I study the productivity effects of corporate diversification, where productivity is understood as a measure of sales per input at the productive unit level, and diversified firms are defined as firms that operate in different industries. I develop and...
With the advances in electronics and communication devices over the last several decades, radio-frequency antennas have miniaturized from externally mounted “rabbit ears” on our grandma’s televisions to devices small enough to be concealed within the body of the cellphone itself, corresponding to the carrier frequencies used from on the order...
This dissertation contains three results related to modular forms and Galois representations of low weight. In chapter 1, we prove that the Galois pseudo-representation valued in a Hecke algebra which acts faithfully on a space of weight one Katz modular forms of level prime to p is unramified at p....
This dissertation, “Altered Belonging: The Transnational Modern Dance of Itō Michio,” argues that Itō forged an artistic and social identity out of the very categories of racial and national difference typically used to exclude Japanese from Euro-American society. The strategies he employed provide a paradigm for how performing bodies marked...
Traditionally, simulation analysis has focused on designing a computationally efficient algorithm assuming a correct simulation model is given. As computation becomes cheaper, we are now able to perform more sophisticated simulation analyses involving extensive computation and consider all sources of errors in the simulation model and their effects to the...
The floor plate (FP) is a ventral midline organizing structure of the developing neural tube that provides positional information using morphogen concentration gradients towards the production of diverse neuron types. In caudal regions the FP is non-neurogenic unlike the mesodiencephalic region of the FP that is highly neurogenic, and is...
In this thesis, we advocate for the use of slice spheres, a common generalization of representation spheres and induced spheres, in parameterized homotopy theory. First, we give an algebraic characterization of the layers of the Hill-Hopkins-Ravenel slice filtration.
Next, we explore the homology of parameterized symmetric powers from this point...
This dissertation explores the relationship between dance cultures and media cultures in the United States between the 1940s and the 1960s, when both were experiencing a period of multiplicity and flux in their forms. Bringing together theories and methodologies from dance studies, media studies, and cultural history, it considers how...
This dissertation analyzes theater performances that use narratives of U.S. military veterans in the post 9/11 era in order to cross the military-civilian divide. Engaging theories of performance, embodiment, and affect, this project investigates the depiction of military bodies onstage, the public perception of military identities, and the lived experience...
Our capacity to share ideas through content is the paramount feature of the human brain. All of our species’ advanced communication and coordination fundamentally relies on our ability to “think alike,” yet the parallels between our brains are grossly understudied, especially regarding engagement with dynamic audiovisual stimuli. Therefore, we present...
Spatial-temporal data mining, with data driven model and machine learning techniques, significantly benefit the traditional transportation research. This dissertation focus on three problems related to uncertain location data, lane-level traffic speed clustering and anomalous traffic speed prediction.
We take a first step towards combining the uncertain location data i.e., fusing...
Thermal overheating is a serious concern in modern supercomputing systems. Elevated temperature levels reduce the reliability and the lifetime of the underlying hardware and increase their power consumption. Previous studies on mitigating thermal hotspots at the hardware and run-time system levels have typically used approaches that trade off performance for...
Free radical polymerization has a wide range of applications and continues to attract research interest as the demand for tailored specialty polymers grows. Sequence distribution, tacticity and composition of copolymers play a key role in understanding the reaction kinetics and the properties of the polymers 1. One of the chief...
Recent scholarship in critical urban theory, urban political ecology, and related fields has emphasized the "hybridity" of urban-environmental systems. This argument is contrasted with the socially constructed "binary" relationship between "city" and "nature" that dominated historical understandings of urban-environmental connections. Despite wide agreement on these issues, the trajectories that precipitated...
This project elaborates an aesthetic politics that treats the possible as the site of a transformative exhaustion. It examines the aberrant temporal movements that are produced by exhaustive procedures, arguing that by disrupting the habitual structure of time, what I refer to as stereoscopic time, they render the present susceptible...
Accurate thermodynamic databases are the foundation of predictive microstructure and property models. An initial assessment of the commercially available Thermo-Calc TCAL2 database and the proprietary aluminum database of QuesTek demonstrated a large degree of deviation with respect to equilibrium precipitate phase prediction in the compositional region of interest when compared...
Circling the Cosmograms marks the first full-length study of second-generation feminist and/or queer art and performance in the Haitian Dyaspora (Haitian Kreyòl spelling) following the January 12, 2010 earthquake in Haiti. Through archival research, visual and performance art analysis, and in-depth interviews, I document the ways feminist and/or queer Haitian-American...
Halide perovskites, AMX3 (A = monocation, B = Ge, Sn, or Pb, and X = halogen), present a versatile class of solution-processable semiconductors made from earth abundant materials with outstanding electrical and optical properties. Their solar cell efficiencies have dramatically increased from ~9% to ~22% in less than five years...
Ecological restoration is vital to the conservation of biodiversity and provision of ecosystem services in a changing world. Biodiversity is often a goal of restoration, and species to be planted for restoration are often selected based on diversity objectives. But species are not independent; they are related to one another...
Seismic waves from large-magnitude earthquakes sometime trigger small secondary earthquakes or tectonic tremor. These secondary signals are important to observe and study because their occurrence reflects on the state of stress of the subsurface, which is important for hazard assessment. Here we first report on how individual inspection by a...
Bacterial gene expression requires numerous steps that are energetically costly and tightly regulated. Following transcription of messenger-RNA, the translation of mRNA into protein is further regulated by a variety of sequence features both within and upstream of coding sequences. Collectively, these features contribute to the control of translation initiation, elongation,...
How do independent artists use social media and e-commerce websites to support their creative businesses? This dissertation examines independent artists’ participation in the peer economy for selling handmade goods, a hybrid economy that combines sharing content on social media and selling goods on e-commerce platforms. While a multidisciplinary array of...
This dissertation asks how deepening global inequalities reshape the ways families negotiate “economic moralities,” normative expectations of material obligation and entitlement. It focuses on the families of middle class migrants: French-educated Senegalese urbanites whose diplomas no longer protect them from discrimination in Paris but who, among Africans, are still construed...
In today's marketplace, consumers purchase a basket of goods of different categories from many different types of retail stores. While most marketing literature focuses on studying a single retail chain or a single category, my dissertation considers consumers' collective basket purchases across different retail formats. By doing so, my dissertation...
Over the past two decades, optical coherence tomography (OCT) has been successfully applied to various fields of biomedical researching and clinical studies, including cardiology, urology, dermatology, dentistry, oncology, and most successfully, ophthalmology. This dissertation seeks to extend the current OCT practice, which is still largely morphology-based, into a new dimension,...
Web users suffer from security and privacy threats. According to Symantec, 430 million new unique pieces of malware have been discovered in 2015, and over half a billion personal records were stolen or lost in the same year. Defense mechanisms can be classified as reactive approach and proactive approach. Reactive...
Optical quantum communication (QC) has the potential to address the demands of high-speed and maximally-secure communication. In optical QC, information is encoded onto the state of photons. By using entangled photonic states, QC protocols can support fundamentally secure communication for applications which cannot use classical information. To increase the information...
This dissertation develops a theory of rebel-state engagement during armed conflict that links these varied interactions to processes of institutional change in the state in which they unfold. Conventional wisdom portrays conflict zones as lacking institutions or pitting armed groups and states as competitors. Yet, this dissertation finds that rebels...
This dissertation focuses on exploring novel light steering and spectral engineering functionalities by flat optics, which includes photonic architectures of flat plasmonic metasurfaces, nanoparticle arrays, and thin film coatings. We have designed, fabricated and characterized different plasmonic metasurfaces (trapezoid-shaped antennas, nanorings/nanowires, etc.), nanoparticle arrays (single-layered or multilayered nanocubes and nanodisks),...
This dissertation examines the situated and interactional nature of cultural experiences. Drawing on the literature on materiality, place, and space, the study analyzes how the physical and spatial characteristics of art galleries and art museums in Accra, Ghana, and Johannesburg, South Africa, lead people to engage with culture, and derive...
Simulation analytics treats stochastic simulation as data analytics for systems that do not yet exist, and extends traditional performance estimation and system optimization to uncovering underlying patterns and the key drivers and dynamics of system behavior by retaining the sample paths generated throughout simulation runs. My dissertation addresses two research...
This dissertation casts an aesthetic light on a selection of polyphonic novels from the Francophone contemporary canon. From the forms of feminism around the prophet of islam in Far from Madina by Assia Djebar, to the multiple voices of Créolité in Solibo Magnificent by Patrick Chamoiseau, to the forms of...
Topoisomerases are ubiquitous enzymes involved in maintaining the supercoiled state of DNA in the cell. Structural, biophysical, and biochemical studies have provided an overall view of the mechanisms of DNA transformation by these enzymes, but many aspects, particularly their dynamic characteristics, remain poorly understood. Type IA topoisomerases change the topology...
SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...
A failure to effectively regulate emotions elicited by a stressful life event contributes to symptoms of psychopathology. This regulatory failure may result from a deficit in executive control. For some individuals, executive control is impaired following stress exposure. Thus, for some individuals, when executive control is needed to regulate emotions...
Ross (2015) proposed a recovery theorem which uses prices of contingent claims to recover market’s expectations about underlying asset returns. His work relies on two assumptions. He assumes all uncertainty of the economy follows a finite state irreducible Markov chain and that the pricing kernel is transition independent. We first...
“The Vicarious Middle Ages” investigates the religious and cultural history of proxy penance where medieval Christians believed that it was possible to suffer on behalf of another person. In proxy penance, one person completed a penitential work for another, who received the spiritual benefit. From the third until the sixteenth...
Phase separation in segmented polymers provides distinct challenges in regard to their chemical reaction kinetics and characterization. Well studied, it has been shown that structure, phase separation and non-covalent interactions are key factors in the design of elastomeric polyurethanes. Specifically, this dissertation is focused on two areas: the synthesis of...