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-
- Description:
- Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) represent a class of non-canonical, ganglion cell photoreceptors. These cells influence a variety of visual behaviors including contrast sensitivity, circadian photoentrainment, sleep, and even mood. These wide-ranging behavioral influences are attributed to the multiple subtypes (M1-6) that comprise the ipRGC population, with different...
- Keyword:
- Development, ipRGCs, Melanopsin, and Retina
- Subject:
- Neurosciences and Developmental biology
- Creator:
- Lucas, Jasmine Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_744013 and http://dissertations.umi.com/northwestern:15132
-
- Description:
- The cerebellar cortical system is an extensively studied circuit which is critical for motor learning. While multiple monoamines, such as norepinephrine and serotonin, modulate cerebellar cortical output, the mechanistic details of dopaminergic signaling in the cerebellum remain poorly understood. Additionally, neuronal cell types residing within the cerebellum remain relatively under-characterized....
- Keyword:
- Cerebellum, Dopamine, Unipolar brush cells, and Light sheet microscope
- Subject:
- Neurosciences
- Creator:
- Canton-Josh, Jose Ernesto
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15996 and etdadmin_upload_896041
-
- Description:
- Research on how sleep contributes to memory has blossomed in recent years. These studies have generally focused on whether or not sleep impacts various types of memory independently. An open question is whether sleep interactively influences different memory types. My research focuses on two types of memory—specificity and generalization. Whereas...
- Keyword:
- memory, sleep, generalization, memory consolidation, and targeted memory reactivation
- Subject:
- Cognitive psychology, Psychobiology, and Neurosciences
- Creator:
- Witkowski, Sarah (Sadie)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15250 and etdadmin_upload_763727
-
- Description:
- Autism spectrum disorder (ASD) and intellectual disability (ID) are two of the most highly prevalent neurodevelopmental disorders (NDDs), each affecting roughly 2% of the population. Despite the need for therapies, few exist due to a myriad of challenges, such as the complex underlying genetic etiology and historic inaccessibility of neural...
- Keyword:
- PACS1 syndrome, Induced pluripotent stem cells, Single-cell RNA sequencing, Intellectual disability, Cerebral organoids, and Autism spectrum disorder
- Subject:
- Molecular biology and Neurosciences
- Creator:
- Rylaarsdam, Lauren Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_984633 and http://dissertations.umi.com/northwestern:16538
-
- Description:
- The exchange of information in the brain is accomplished through sequences of action potentials that result from the integration of local microcircuits. Unraveling the connectivity of the neurons that constitute these microcircuits and how they contribute to network activity is vital for understanding how information is relayed through the brain...
- Subject:
- Neurosciences
- Creator:
- Fiske, Michael Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15476 and etdadmin_upload_797275
-
- Description:
- We perform many movements every day without much deliberation. However, moving can be seen as a form of decision-making since one of many possible movements must be selected and executed. The decision-making processes that underlie movements are influenced by various factors, including sensory perception, energetics, time, perceived rates of failure...
- Keyword:
- hind brain, reticulospinal, decision, escape, spinal cord, and looming
- Subject:
- Biomedical engineering, Neurosciences, and Biomechanics
- Creator:
- Bhattacharyya, Kiran
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_653282 and http://dissertations.umi.com/northwestern:14560
-
- Description:
- We present two ways in which measures of information can be used for the design and analysis of neural networks in both the brain and the computer. In the brain, stimulus is often represented as a distributed pattern of activity in a network of neurons. The quality of such population...
- Keyword:
- Neural Coding, Fisher Information, Memory, Neural Networks, Population Coding, and Information Theory
- Subject:
- Artificial intelligence, Neurosciences, and Biophysics
- Creator:
- Kim, Hyun Jin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_764291 and http://dissertations.umi.com/northwestern:15264
-
- Description:
- Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
- Subject:
- Neurosciences
- Creator:
- Nguyen, Maria Bac-Ai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14484 and etdadmin_upload_630756
-
- Description:
- Vertebrate brains evolved to facilitate a diverse array of behaviors and internal cognitive processes. Theories of neural function have proposed that neural computation is organized within populations or ensembles of neurons. Here, we identify ensembles of neurons in the striatum, the main input nucleus of the basal ganglia, in which...
- Keyword:
- Wireless Optogenetics, Basal Ganglia, Striatum, Dopamine, Neural Ensemble, and Population Activity
- Subject:
- Neurosciences
- Creator:
- Minkowicz, Samuel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16515 and etdadmin_upload_983540
-
- Description:
- Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
- Keyword:
- rumination, women's health, depression, and white matter
- Subject:
- Clinical psychology, Psychology, and Neurosciences
- Creator:
- Satyshur, Maureen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_676234 and http://dissertations.umi.com/northwestern:14751
-
- Description:
- New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
- Keyword:
- running, Fragile X, adult neurogenesis, GABA, dentate gyrus, and synapse
- Subject:
- Neurosciences
- Creator:
- Remmers, Christine L
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_634151 and http://dissertations.umi.com/northwestern:14492
-
- Description:
- Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
- Keyword:
- microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- McGee, Warren A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037
-
- Description:
- Temperature affects all biological processes, from the rate of cellular growth and metabolism to the stability of proteins that make up the machinery of life itself. Thus, all organisms must have the capacity to detect and respond to external temperature. Thermosensation endows animals with the ability to sense and respond...
- Keyword:
- behavior, thermosensory, drosophila, and neural circuit
- Subject:
- Neurosciences
- Creator:
- Jouandet, Genevieve
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16434 and etdadmin_upload_965903
-
- Description:
- Coordinated movement relies on the precise and controlled activation of populations of motor units, which convert the commands of the nervous system into muscle forces. Motor unit firing patterns are often nonlinear and generated through the response to a combination of ionotropic excitatory and inhibitory commands, as well as metabotropic...
- Keyword:
- Motor Unit, Stroke, Persistent Inward Currents, Delta-F, Motoneuron, and Aging
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Hassan, Altamash Shamsul
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15718 and etdadmin_upload_843639
-
- Description:
- Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
- Keyword:
- Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Murnan, Kevin Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864
-
- Description:
- Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
- Keyword:
- aging, tractography, olfaction, alzheimer's disease, orbitofrontal cortex, and diffusion magnetic resonance imaging
- Subject:
- Neurosciences
- Creator:
- Echevarria-Cooper, Shiloh Luela
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16387 and etdadmin_upload_952134
-
- Description:
- Processing of sensory information in the brain is a pervasive and fundamental phenomenon across animal species and is involved in both "hard-wired" innate responses as well as learned and adaptive behaviors. Here, I show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity and complex processing...
- Keyword:
- systems neuroscience, sensory navigation, modeling, drosophila, thermosensation, and neural circuits
- Subject:
- Applied mathematics, Biology, and Neurosciences
- Creator:
- Levy, Joshua
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_836701 and http://dissertations.umi.com/northwestern:15663
-
- Description:
- The cerebellum is involved in sensorimotor processing and motor control in the brain. What has been found across many species for many behaviors is cerebellar Purkinje (Pkj) cells and cerebellar nuclear (CbN) cells show activity that is related to and predictive of movements. Less is known about how patterns of...
- Subject:
- Neurosciences
- Creator:
- Brown, Spencer T
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669457 and http://dissertations.umi.com/northwestern:14720
-
- Description:
- Decisions in naturalistic environments usually feature delayed and uncertain outcomes that can only be reached after a sequence of actions are performed. For example, canonical stalking and pursuit strategies used by terrestrial predators often involve stages of concealment, pauses where the predator remains motionless, and high speed chase sequences. The...
- Keyword:
- Ecology, Evolution, Decision Making, and Computational Neuroscience
- Subject:
- Ecology, Biomedical engineering, and Neurosciences
- Creator:
- Mugan, Ugurcan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_769384 and http://dissertations.umi.com/northwestern:15318
-
- Description:
- Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
- Keyword:
- induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction
- Subject:
- Molecular biology and Neurosciences
- Creator:
- Stojkovska, Iva
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793