Over the past fifty years, techniques for synthesizing and manipulating matter on the 1-100 nanometer scale have led to the development of nanoparticle-based approaches to both disease diagnosis and treatment. The modification of nanoparticles with biological macromolecules such as proteins and nucleic acids has led to the development of highly...
Neural stem and progenitor cell (NPC) fate specification is a crucial component of central nervous system development, and the myriad signaling pathways that guide it are poorly understood. In my thesis work, I aimed to elucidate signaling mechanisms of the bone morphogenetic protein family (BMP) and some of its targets...
Popular and scholarly arguments state that uncivil discourse is bad for democracy because it hampers political trust and sharpens polarization. These same scholars see uncivil discourse as contrary to a good democratic society. However, their arguments could be overstated because incivility may be so contextual that elites can frame certain...
Atrial fibrillation (AF) is the most common arrhythmia in adults in the United States. Despite its prevalence, the etiology of AF and its adverse effects are not completely understood, which has made treatment of AF difficult. However, left atrial (LA) fibrosis is associated with worsening and propagating AF. Additionally, research...
This dissertation studies topics in health care operations management related to value-based care, where {\em value} can be thought of as the ratio of quality to cost. The objective in value-based care is to increase, or maximize, value by reducing costs and improving quality health outcomes. In Chapter 1 we...
The mechanism underlying chronic pain and disability in those with chronic whiplash associated disorders (WAD) is poorly understood. Of the four million people who will seek medical care each year for neck injuries sustained during a motor vehicle collision (MVC), a quarter will develop chronic moderate to severe WAD. Disparate...
This dissertation is a broad study on individual and firm-level financial conditions and their effects on politics. In the first chapter, I study the effect of economic conditions on political polarization using micro-data on house prices, mortgages, and individual political contributions. I argue that shocks to housing wealth --- the...
The study of solid-state organic chromophores has been soaring in the last decade owing to their wide applications in organic photovoltaics. These organic chromophores can absorb light in the visible region and form free charge carriers with proper design in molecular structure and device fabrication. In solid state, chromophores are...
Knowledge combination is a fundamental component of technological invention, which is a driver of new economic opportunities and firm growth. Yet, evidence suggests that myriad organizational factors, including managers, weigh heavily on the ability of firms to productively use R&D capabilities. This dissertation argues that managerial attention plays an important...
This thesis revisits classic optimal tax theory, recognizing that most people live in multi-person households. We derive optimal tax schedules for married agents, seriously taking the distinction between interpersonal and interhousehold inequality. After showing how individual-oriented utilitarianism typically leads to a misalignment between the households’ and the government’s objectives, which...