The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex, composed of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor's differential processing of various pri-miRNAs. Here, I show...
This dissertation examines how filmic, literary, and popular musical performances of black female sexualities in the post- civil rights era both reveal and frustrate state-sanctioned infringements on black freedom. “The Paradox of Black Freedom: Black Female Sexuality in Contemporary Performance, 1965-2000” elucidates a powerful paradox wherein the US state enacts...
High-dimensional data are becoming increasingly available in various fields as data collection technology advances. Not only are we interested in knowing which variables are relevant to the response and which are not, but also a simpler model with less predictor variables is easier for interpretation and computational purposes. Furthermore, a...
This dissertation examines the gradual construction and contested meanings of U.S. slavery’s first western border. According to most historiography, Congress’s Northwest Ordinance of 1787 fixed the meaning of this border at the nation’s inception, constituting the Northwest Territory as the free opposite of slave territories south and west of the...
MoS2 is a ubiquitous catalyst for hydrogenation and hydrogenolysis reactions for hydrotreating of petroleum sources for the removal of sulfur and nitrogen containing compounds. Through exploration of this activity, structural models for MoS2 as a series of stacked S-Mo-S platelets held together by Van der Waals forces has been developed....
Education researchers have recently highlighted income achievement and behavior gaps – differences between children from high versus low income families in achievement scores and teacher-rated behavior. To date, scholars in this research stream have not considered the possibility that, compared to white students, non-white students may receive differential returns to...
Across all levels of education, persistent academic achievement gaps exist between students from higher and lower socioeconomic status (SES) backgrounds. Despite these daunting odds, many students from lower-SES backgrounds manage to maintain high levels of academic motivation and persist in the face of difficulty. One factor that has been shown...
Nucleosome organization influences gene activity by controlling DNA accessibility to transcription machinery. In this thesis, we have developed a chemical biology approach to determine mammalian nucleosome positions genome-wide. Using this strategy, we uncover surprising new features of nucleosome organization in mouse embryonic stem cells. In contrast to the prevailing model,...
Woodstock—the word is shorthand for the spirit of the 1960s counterculture. Yet the assumption that the 1960s dawned a “New Age” neglects contributions made by earlier generations of Woodstock artists in advancing a utopian vision of emancipated art, life, and labor. From 1902 onwards, Woodstock—a small Dutch hamlet in upstate...
In the last twenty years, memory entrepreneurs have proliferated memories of Communism from Central and Eastern Europe transnationally across Europe, but for some an invisible Iron Curtain persists. How has the European memory field changed in the last two decades, and more broadly, what determines which mnemonic actors are successful...
Analytic jurisprudence is the field organized around the “What is law?” question. When most scholars approach the “What is law?” question, they suppose that the goal of such inquiry is to discover, or to accurately represent, the true nature of law. Consequently, these scholars reject the notion that the goal...
FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...
"Migration Forms” centers on the place where migration and Morocco meet to tell two stories. One argues for the centrality of migration to the projects of local, contemporary art making and postcolonial nation building, while the other examines the codification, circulation, and contestation through visual form of this North African...
An important question in religious and theological ethics concerns the human capacity for moral action, but contemporary Christian theological anthropologies largely theorize the human person in terms of the imago Dei, not moral subjectivity. The following study contributes to this challenge an investigation of human moral agency in the theological...
After 9/11 there was a shift in the rhetoric surrounding counter-terrorism. Suddenly, the language of risk, security and prevention was being utilized to justify a new set of global financial regulations headed up by international organizations such as the United Nations, The Financial Action Task Force, and the IMF/World Bank....
In March 1977 an exceptionally strong earthquake struck Romania ruled by the communist president and dictator Nicolae Ceauşescu and his regime. The policies and actions implemented and undertaken in the days, weeks, and year that followed were forms of aftershocks. The Ceauşescu regime modeled the 1977 earthquake recovery on previous...
Founded in Oakland, California, in 1966 to confront the crisis of anti-black police violence in the Bay Area, the Black Panthers advocated armed struggle against the violences and aggressions of racist American imperialism domestically and internationally. Against interpretations that would deem their image-making to be secondary to their professed political...
This dissertation analyzes theater performances that use narratives of U.S. military veterans in the post 9/11 era in order to cross the military-civilian divide. Engaging theories of performance, embodiment, and affect, this project investigates the depiction of military bodies onstage, the public perception of military identities, and the lived experience...
Our capacity to share ideas through content is the paramount feature of the human brain. All of our species’ advanced communication and coordination fundamentally relies on our ability to “think alike,” yet the parallels between our brains are grossly understudied, especially regarding engagement with dynamic audiovisual stimuli. Therefore, we present...
Recent scholarship in critical urban theory, urban political ecology, and related fields has emphasized the "hybridity" of urban-environmental systems. This argument is contrasted with the socially constructed "binary" relationship between "city" and "nature" that dominated historical understandings of urban-environmental connections. Despite wide agreement on these issues, the trajectories that precipitated...