Much has already been discovered about the Hedgehog (Hh) signaling pathway and its involvement in patterning and tissue development in embryos, but the specific functions its key components play has not yet been fully elucidated. One potential component is the protein kinase Dop, which is involved in cellular trafficking. Here,...
This project was originally motivated by a lifelong love of the Harry Potter series and a teenage love for fan fiction and other fancreated works. I was motivated to do research when I stumbled upon the lack of inclusivity in many fan communities, which I found to be shocking. In...
The E-Science Working group designed a survey in 2013 to investigate how researchers at Northwestern University manage data and to help determine researchers’ needs or requirements for data storage, preservation and sharing.
The 21 question survey looked at several areas involving data and data management, including the types and size...
Chapter 1 investigates asks the question how do financial frictions affect the type of human capital investments that students make in college? To study this question, I build a novel dataset covering more than 700,000 U.S. students, merging commencement records with address histories, credit bureau records, and professional resumes. I...
Early life adversity predicts greater health risk in later life across multiple outcomes, including cardiovascular disease (CVD) and all-cause mortality. While biological pathways are incompletely understood, evidence is increasingly highlighting immune function, specifically chronic inflammation, which is implicated in cardiometabolic diseases, certain cancers, and all-cause mortality. Links between early adversity...
Importance: Despite its efficacy, low tidal volume ventilation (LTVV) remains severely underutilized for patients with acute respiratory distress syndrome (ARDS). Physician under-recognition of ARDS is a significant barrier to LTVV use. We propose a computational method that addresses some of the limitations of the current approaches to automated measurement of...
Chapter 1. Undergraduate Gender Diversity and Direction of Scientific Research (with Francesca Truffa) Can diversity lead to greater research focus on populations underrepresented in science? Diverse researchers can bring new questions and perspectives, but exposure to diversity may also inspire scientists, regardless of demographic identity, to pursue new topics. This...
This work is composed of two separate projects that contribute to the field’s understanding of Neisseria gonorrhoeae genetics and physiology. First, I showed that N. gonorrhoeae mounts a substantial transcriptional program in response to hydrogen peroxide (HP), a prominent reactive oxygen species (ROS) encountered during infection. We measured which strain...
Evolutionary theory predicts that reproduction entails energetic costs that detract from somatic maintenance, accelerating biological aging. In women, such ‘costs of reproduction’ (CoR) are thought to arise predominantly during pregnancy and lactation, while in men the physiological effects of the steroid hormone testosterone (T) are believed to be a major...
The high-temperature oxidation/reduction behaviors of iron and its oxides are important to a variety of energy conversion and storage technologies, such as the solid-oxide iron-air battery and chemical looping combustion. The useful lifetime of iron redox materials is limited, however, by structural degradation arising from (i) sintering, accelerated by phase...