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Filtering by: Creator Andrea Calvert Keyword Glioblastoma (GBM) Keyword targeted therapy Keyword wild-type IDH1 Subject Driskill Graduate Training Program in Life Sciences

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1. Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Description:: Metabolic abnormalities of cancers provide opportunities for novel tumor-specific therapies. Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG) and the reduction of NAD(P)+ to NAD(P)H. Oncogenic mutations in two IDH-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma...
Keyword:: lipids, Glioblastoma (GBM), targeted therapy, wild-type IDH1, NADPH, and metabolism
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Andrea Calvert
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/27/2018
Date Modified:: 04/27/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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1. Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation