Northwestern University

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Filtering by: Creator Anne Marie Strohecker Subject Integrated Graduate Program in the Life Sciences

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Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

Description:

Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...

Keyword:

HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Anne Marie Strohecker

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/30/2018

Date Modified:

07/30/2018

Date Created:

05-15-2007

Resource Type:

Dissertation