Cell state transitions are often triggered by large changes in the
concentrations of transcription factors and therefore large differences
in their stoichiometric ratios. Whether cells can elicit transitions using
modest changes in the ratios of co-expressed factors is unclear. Here,
we investigate how cells in the Drosophila eye resolve state...
Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...
