Northwestern University

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Filtering by: Creator Foote, Kendall Marie Resource type Dissertation Subject Neurosciences

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Phosphorylation of TRIP8b Modulates Binding to HCN Channels and is Dysregulated in Temporal Lobe Epilepsy

Description:

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are non-selective cation channels expressed in the brain and heart where they exert control over many diverse physiological properties. In the hippocampus, HCN channels are enriched in a dendritic gradient within CA1 pyramidal cells where they reduce dendritic integration and dampen neuronal excitability. HCN channels...

Keyword:

Temporal Lobe Epilepsy, HCN channels, Phosphorylation, and TRIP8b

Subject:

Neurosciences

Creator:

Foote, Kendall Marie

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_682272 and http://dissertations.umi.com/northwestern:14781