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Inhibition of amyloid beta oligomer formation, binding, and downstream tau phosphorylation: three potential therapeutic approaches for Alzheimer’s disease

Description:

Amyloid beta oligomers (AβOs) are a key instigator of neurodegeneration in Alzheimer’s disease (AD). The work presented in this thesis includes three disease-modifying approaches to disrupt pathological AβO-related mechanisms in AD: (1) inhibiting AβO buildup, (2) blocking AβO-induced tau phosphorylation, and (3) neutralizing AβOs. These three approaches were tested in...

Keyword:

Amyloid beta oligomer

Subject:

Chemistry

Creator:

Johnson, Elizabeth Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16421 and etdadmin_upload_962600
Inhibition of amyloid beta oligomer formation, binding, and downstream tau phosphorylation: three potential therapeutic approaches for Alzheimer’s disease

Description:

Amyloid beta oligomers (AβOs) are a key instigator of neurodegeneration in Alzheimer’s disease (AD). The work presented in this thesis includes three disease-modifying approaches to disrupt pathological AβO-related mechanisms in AD: (1) inhibiting AβO buildup, (2) blocking AβO-induced tau phosphorylation, and (3) neutralizing AβOs. These three approaches were tested in...

Keyword:

Amyloid beta oligomer

Subject:

Chemistry

Creator:

Johnson, Elizabeth Anne

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

03/24/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16421 and etdadmin_upload_962600

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Inhibition of amyloid beta oligomer formation, binding, and downstream tau phosphorylation: three potential therapeutic approaches for Alzheimer’s disease

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