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Filtering by: Creator Jonathan Brooks Bell Type Work Keyword Glioma stem cells Keyword MAPK-interacting kinase Subject Driskill Graduate Training Program in Life Sciences

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MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

Description:

MAPK-interacting kinase (MNK) signaling leads to activation of cap-dependent mRNA translation through phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E). In cancer cells, MNK-eIF4E signaling promotes translation of oncogenic mRNAs. In glioblastoma (GBM), the deadliest malignant brain tumor, MNK-eIF4E signaling is aberrantly activated and represents a promising therapeutic target....

Keyword:

MAPK-interacting kinase, Glioblastoma, and Glioma stem cells

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Jonathan Brooks Bell

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/26/2018

Date Modified:

10/26/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

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MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma