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- The development of the deconstruction approach was supported by the National Science Foundation through the support of the SynBAS NRT program (2021900).1
- This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program. 1
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- Description:
- These supplementary materials are in support of the manuscript "Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists," in which we describe a framework for synthetic biology training that deconstructs biotechnologies across scales—molecular, circuit/network, cell/cell-free systems, biological communities, and societal—giving students a holistic toolkit to integrate cross-disciplinary...
- Keyword:
- Synthetic Biology and Education
- Creator:
- Northwestern Center for Synthetic Biology, Ashty S. Karim, and Julius B. Lucks
- Contributor:
- The development of the deconstruction approach was supported by the National Science Foundation through the support of the SynBAS NRT program (2021900).
- Owner:
- Ashty Stephen Karim
- Date Uploaded:
- 03/11/2024
- Date Modified:
- 03/11/2024
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- Description:
- Recent advances in cell-free synthetic biology have spurred the development of in vitro molecular diagnostics that serve as effective alternatives to whole-cell biosensors. However, cell-free sensors for detecting manmade organic water contaminants such as pesticides are sparse, partially because few characterized natural biological sensors can directly detect such pollutants. Here,...
- Keyword:
- biosensor, TX-TL, atrazine, cell-free, cyanuric acid, metabolism, synthetic biology, and transcription factor
- Creator:
- Umut Akova, Khalid K. Alam, Michael C. Jewett, Julius B. Lucks, and Adam D. Silverman
- Owner:
- Adam Silverman
- Date Uploaded:
- 09/23/2019
- Date Modified:
- 02/19/2020
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- Description:
- Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
- Keyword:
- Diagnostic, Fluoride, Riboswitch, Cell-Free, and Synthetic Biology
- Subject:
- Synthetic Biology and Diagnostics
- Creator:
- Nancy Kelley-Loughnane, Matthew S. Verosloff, Michael C. Jewett, Walter Thavarajah, Julius B. Lucks, and Adam D. Silverman
- Contributor:
- This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program.
- Owner:
- Julius Beau Lucks
- Language:
- English
- Date Uploaded:
- 06/18/2019
- Date Modified:
- 01/08/2020
- Date Created:
- 2019-06-04
- Resource Type:
- Dataset
- Alternate Identifier:
- https://doi.org/10.21985/N2RJ64
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- Description:
- Recent advances in cell-free gene expression (CFE) systems have enabled their use for a host of synthetic biology applications, particularly for rapid prototyping of genetic circuits and biosensors. Despite the proliferation of cell-free protein synthesis platforms, the large number of currently existing protocols for making CFE extracts muddles the collective...
- Keyword:
- cell-free synthetic biology, TX-TL, CFE, cell extract, genetic circuitry, in vitro protein synthesis, CFPS, and endogenous transcription
- Subject:
- Synthetic biology and Genetic regulation
- Creator:
- Nancy Kelley-Loughnane, Michael C. Jewett, Julius B. Lucks, and Adam D. Silverman
- Owner:
- Julius Beau Lucks
- Publisher:
- American Chemical Society
- Language:
- English
- Date Uploaded:
- 12/14/2018
- Date Modified:
- 01/07/2020
- Date Created:
- 12/14/18
- Resource Type:
- Dataset
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- Description:
- A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
- Keyword:
- transcription, RNA, RNA engineering, synthetic biology, and gene regulation
- Subject:
- Synthetic Biology and RNA engineering
- Creator:
- Matthew Verosloff, Alexandra Westbrook, James Chappell, and Julius B. Lucks
- Owner:
- Julius Beau Lucks
- Publisher:
- MacMillan Publishers
- Language:
- English
- Date Uploaded:
- 08/03/2017
- Date Modified:
- 01/07/2020
- Date Created:
- 2017-08-03
- Resource Type:
- Dataset
- Alternate Identifier:
- doi:10.21985/N28S9B