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Filtering by: Creator Katie L Kathrein Type Work Keyword Ikaros Subject Integrated Graduate Program in the Life Sciences

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1. Defining the role of Ikaros as a tumor suppressor and repressor of Notch target gene expression

Description:: Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...
Keyword:: Notch, Ikaros, tumor suppressor, and RBP-J
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Katie L Kathrein
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/01/2018
Date Modified:: 09/01/2018
Date Created:: 2008-02-22
Resource Type:: Dissertation