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Filtering by: Creator Kuehnle, Neil Joseph Keyword DR4

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The Role of FLICE-Inhibitory Proteins in Primary Effusion Lymphoma

Description:

Kaposi’ sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). PEL cell lines require expression of the cellular FLICE inhibitory protein (cFLIP) for survival, although KSHV encodes a viral homolog of this protein (vFLIP). Cellular and viral FLIP proteins have several functions, including, most importantly, the inhibition of pro-apoptotic caspase 8...

Keyword:

cFLIP, DR4, TRAIL-R1, cell death, HHV-8, and primary effusion lymphoma

Subject:

Microbiology and Biology

Creator:

Kuehnle, Neil Joseph

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

08/23/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16705 and etdadmin_upload_1010776