Northwestern University

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Filtering by: Creator Murthy, Tushar Resource type Dissertation

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CDK-dependent phosphorylation and disease-associated mutations in distinct regions of splicing factor 3B1 (SF3B1) influence its interaction with chromatin and RNA.

Description:

Splicing factor 3B1 (SF3B1) is a core splicing protein that stabilizes the interaction between the U2 snRNA and the branch point (BP) in the RNA target during splicing. SF3B1 is heavily phosphorylated at its N terminus and a substrate of cyclin-dependent kinases (CDKs). Although SF3B1 phosphorylation coincides with splicing catalysis,...

Subject:

Molecular biology

Creator:

Murthy, Tushar

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14407 and etdadmin_upload_617912