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Filtering by: Creator Sarah Lynn Kerns Resource type Dissertation

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Control of DNA Replication by the Cdt1/Geminin Complex

Description:

It is critical to genomic integrity that DNA is replicated completely and faithfully during each cell cycle. The essential replication factor Cdt1 is a critical protein in preventing reinitiation of replication. Overexpression of Cdt1 causes re-replication in p53 null cells and transforms NIH3T3 cells, causing them to form tumors in...

Keyword:

Xenopus, Cell Cycle, Geminin, Cdt1, and Re-Replication

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Sarah Lynn Kerns

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/01/2018

Date Modified:

06/01/2018

Date Created:

2007-05-11

Resource Type:

Dissertation