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Microprocessor Recruitment to RNA Polymerase II is Required for Differential Expression of MicroRNAs

Description:

The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex, composed of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor's differential processing of various pri-miRNAs. Here, I show...

Keyword:

Molecular Biology

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Victoria Anne Church

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/09/2019

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation