Northwestern University

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Filtering by: Creator Wadhwani, Anil R Resource type Dissertation

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Endogenous Apolipoprotein E4 modulates a sporadic Alzheimer’s disease phenotype in human stem-cell derived neurons

Description:

The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...

Keyword:

APOE, Alzheimer, Stem Cells, and CRISPR

Subject:

Molecular biology, Medicine, and Neurosciences

Creator:

Wadhwani, Anil R

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542