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Filtering by: Creator William Edward Putzbach Resource type Dissertation

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Toxicity Mediated by Seed-Dependent Off-Target Effects in RNA Interference

Description:

Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...

Keyword:

siRNA, RNA Interference, Cell Death, Cancer, shRNA, and DISE

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

William Edward Putzbach

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/01/2019

Date Modified:

04/01/2019

Date Created:

2018-01-01

Resource Type:

Dissertation