Northwestern University

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Filtering by: Creator William Sillers Type Work Subject Chemical and Biological Engineering

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METABOLIC ENGINEERING OF CLOSTRIDIUM ACETOBUTYLICUM FOR ENHANCED BUTANOL PRODUCTION AND SELECTIVITY

Description:

To increase the butanol titers and selectivity in <em>Clostridium acetobutylicum</em> we replaced the promoter of the alcohol/aldehyde dehydrogenase (<em>aad</em>) gene with the phosphotranbutyrylase (<em>ptb</em>) promoter and combined this with CoAT downregulation to minimize acetone production. This led to early production of high alcohol (butanol plus ethanol) titers and overall solvent...

Keyword:

metabolic engineering and Clostridium acetobutylicum

Subject:

Chemical and Biological Engineering

Creator:

William Sillers

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/01/2018

Date Modified:

10/01/2018

Date Created:

2008-12-04

Resource Type:

Dissertation