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Ultra-high dimensional variable selection with application to normative aging study: DNA methylation and metabolic syndrome

Description:

Metabolic syndrome has become a major public health challenge worldwide. The association between metabolic syndrome and DNA methylation is of great research interest. We constructed a binomial model to investigate the association between a metabolic syndrome index and DNA methylation in the Normative Aging Study. We applied the Iterative Sure...

Keyword:

elastic net, Metabolic syndrome, Bootstrap, ultra-high dimensional variable selection, methylation, and ISIS

Creator:

Joel Schwartz, Brian Joyce, Pantel S. Vokonas, Yinan Zheng, Wei Zhang, Lei Liu, Tao Gao, Lifang Hou, Grace Yoon, Weihau Guan, Zhou Zhang, Andrea A. Baccarelli, Wenxin Jiang, and Haixiang Zhang

Owner:

Chris Diaz

Publisher:

BioMed Central

Date Uploaded:

05/10/2017

Date Modified:

05/10/2017

Date Created:

2017-03-07

Resource Type:

Article

Alternate Identifier:

DOI: 10.1186/s12859-017-1568-1