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- Description:
- Nano-scale materials possess many unique physical and chemical properties which are not found in bulk materials. The ability to synthesize these materials by design is one of the greatest challenges in materials science. Advances towards meeting this challenge will lead to discoveries in fields such as plasmonics, photonics, catalysis, and...
- Keyword:
- self-assembly, nanoparticle, DNA, Molecular Dynamics, and Monte Carlo
- Creator:
- Saijie Pan
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 11/24/2019
- Date Modified:
- 11/24/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Systems of colloids coated with high-information polymers are powerful tools for designing crystal lattice with tailorable properties or studying the fundamentals of crystallization. By changing the colloid-colloid interaction strength or colloid shape, different types of lattices can be assembled. In this thesis, I present novel coarse-grained models to describe high-information...
- Keyword:
- DNA, molecular dynamics, nanomaterials, and Colloidal crystallization
- Subject:
- Applied Physics
- Creator:
- Martin Girard
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/21/2019
- Date Modified:
- 10/21/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Spherical nucleic acids (SNAs) are a class of structures composed of spherical nanoparticle cores that are densely functionalized with radially oriented, linear DNA. SNAs exhibit properties that are distinct from those of their linear counterparts. These constructs can readily enter cells, evade nuclease degradation, and bind complementary DNA targets with...
- Keyword:
- Nanoparticles, DNA, Hybridization, Thermodynamics, and Synthesis
- Subject:
- Chemistry
- Creator:
- Lam-Kiu Fong
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/30/2019
- Date Modified:
- 09/30/2019
- Date Created:
- 1/1/2018
- Resource Type:
- Dissertation
-
- Description:
- The rational and deliberate assembly of functional materials from nanoscale building blocks requires a fundamental understanding of interactions between individual components as well as their collective behavior. This thesis investigates the hierarchical organization of nanoparticles using DNA into well-defined three-dimensional materials on the micrometer and millimeter length scales. This assembly...
- Keyword:
- Nanomaterials, Self Assembly, DNA, Colloidal Crystals, Thin Film, and Epitaxy
- Subject:
- Chemical and Biological Engineering
- Creator:
- Mary Wang
- Owner:
- digitalpublishing@northwestern.edu
- Date Uploaded:
- 02/15/2019
- Date Modified:
- 02/15/2019
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
-
- Description:
- The nonlinear optical technique, second harmonic generation (SHG), is applied here for the first time to probe single and double strand DNA (ssDNA and dsDNA) chemically attached to fused quartz/water interfaces. DNA interfaces are often a critical functional component of biodetection, thus, the development of molecular biosensors requires a thorough...
- Keyword:
- biosensors, chirality, second harmonic generation, nonlinear optics, interfaces, and DNA
- Subject:
- Chemistry
- Creator:
- Faith Christianna Boman
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/08/2018
- Date Modified:
- 10/08/2018
- Date Created:
- 2008-12-09
- Resource Type:
- Dissertation
-
- Description:
- This thesis focuses on the design of hybrid organic materials comprising polymers and small molecules for biodiagnostic and electronic applications. Specifically, the electrochemical and fluorescent signaling properties of terthiophene-functionalized polymers are combined with the enhanced recognition properties of DNA hybrid materials, culminating in the development of a "loaded" probe for...
- Keyword:
- Hybrid Materials, DNA, Thiophene, Detection, Polymer Nanoparticles, and Conducting Polymers
- Subject:
- Chemistry
- Creator:
- Brian Richard Stepp
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/01/2018
- Date Modified:
- 10/01/2018
- Date Created:
- 2008-12-05
- Resource Type:
- Dissertation
-
- Description:
- A tetramer model for HIV-1 Integrase (IN) with DNA representing the LTR termini was previously assembled which predicted amino acid residues on the enzyme surface that interact with the LTR termini (Chen et al, 2006). A separate structural alignment of HIV-1, SIV, and ASV INs predicted which of these residues...
- Keyword:
- HIV, DNA, model structure, and Integrase
- Subject:
- Integrated Graduate Program in the Life Sciences
- Creator:
- James Robert Dolan
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/14/2018
- Date Modified:
- 09/14/2018
- Date Created:
- 2008-08-27
- Resource Type:
- Dissertation
-
- Description:
- Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection gonorrhea and is adapted to survive in humans, its only host. The N. gonorrhoeae cell wall is critical for maintaining envelope integrity, resisting immune cell killing, and production of cytotoxic peptidoglycan (PG) fragments. Deletion of the N. gonorrhoeae genes...
- Keyword:
- DNA
- Subject:
- Driskill Graduate Training Program in Life Sciences
- Creator:
- Kyle Patrick Obergfell
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 04/26/2018
- Date Modified:
- 04/26/2018
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
-
- Description:
- DNA is extremely versatile and powerful, both as a construct in biological applications and as a ligand in materials design due to the fact that its recognition properties can be programmed through sequence and length. Spherical nucleic acids (SNAs), nanoparticles surrounded by a dense shell of DNA or RNA, are...
- Keyword:
- Vaccines, DNA, Materials, DNA dendrons, Therapeutics, and Nanoparticle assembly
- Subject:
- Nanoscience and Chemistry
- Creator:
- Distler, Max E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_935338 and http://dissertations.umi.com/northwestern:16301
-
- Description:
- Nucleic acids such as DNA or RNA of various lengths and structures have a wide scope of functions as therapeutic entities compared to conventional drugs. For instance, native and modified forms of nucleic acids can be used for gene silencing, genome editing, gene replacement, immune system modulation, and theranostics. While...
- Keyword:
- lipids, drug delivery, DNA, RNA, and nanoparticles
- Subject:
- Biomedical engineering
- Creator:
- Sinegra, Andrew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_845229 and http://dissertations.umi.com/northwestern:15759
-
- Description:
- Stimuli-responsive colloidal crystals with reconfigurable structures and properties have garnered significant interest in fields focused on the development of on-demand optics, adaptive catalysts, as well as chemical and biological sensors. A variety of different assembly techniques have been developed to engineer colloidal crystals. However, most reported structures are static as...
- Keyword:
- DNA, Colloidal crystals, and Stimuli-responsiveness
- Subject:
- Engineering
- Creator:
- Zhu, Jinghan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15066 and etdadmin_upload_739736
-
- Description:
- Metal-organic frameworks (MOFs) are a class of highly modular materials with welldefined three-dimensional architectures, permanent porosity, and diverse chemical functionalities, which show promise for a wide range of applications, including gas storage and separation, drug delivery, chemical sensing, and catalysis. Nanoparticle forms of MOFs have similar properties but are dispersible...
- Keyword:
- DNA, Nanoparticle, Colloidal crystal engineering, Surface functionalization, and Metal-organic framework
- Subject:
- Chemistry
- Creator:
- Wang, Shunzhi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14463 and etdadmin_upload_626973
-
- Description:
- Proteins are the nanoscale building blocks of life. Their sophisticated but well-defined architectures result in complex biological functions, including ones involved in metabolism, photosynthesis, transcription, translation, and immunity. To study and improve upon the natural functions of proteins, it is desirable to develop methodology for organizing proteins into targeted architectures....
- Keyword:
- Nanotechnology, Protein, Sequence-encoded, DNA, Assembly, and Biomaterial
- Subject:
- Chemistry
- Creator:
- Winegar, Peter Henry
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_927993 and http://dissertations.umi.com/northwestern:16239
-
- Description:
- Gold nanoparticles (AuNPs) display unique characteristics compared to their macro-counterparts that are dependent on shape, size, and attached surface molecules. Methods have been developed to precisely control both size and shape of AuNPs for specific applications. The biocompatibility, plasmonic properties, and ease of functionalization with thiolated molecules, make gold nanoparticles...
- Keyword:
- gold nanopaticles, therapeutics, DNA, cancer vaccine, and plasmonics
- Subject:
- Nanotechnology, Chemistry, and Biology
- Creator:
- Coughlin, Emma
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15532 and etdadmin_upload_815702
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- Description:
- When attached to another species (e.g. a nanoparticle), the sequence specificity of DNA can be repurposed to program interactions between such entities and to direct their formation into ordered structures. The research presented in this thesis aims to push the boundaries of structures that can be made via this approach....
- Keyword:
- image analysis, nanoparticle, DNA, symmetry breaking, high-throughput, and crystal engineering
- Subject:
- Nanotechnology, Chemistry, and Chemical engineering
- Creator:
- Laramy, Christine
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_617692 and http://dissertations.umi.com/northwestern:14404