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Development of a Generalizable Strategy for Converting Metabolite Binding Proteins into Metabolite Responsive Transcription Factors

Description:

Metabolite biosensors are powerful tools for basic biological research, medical diagnostics, and biotechnological applications. However, a generalizable strategy for developing new metabolite biosensors when an existing sensor cannot be found in nature, is a persistent challenge. Furthermore, while transcription factor biosensors have the broadest range of applications, the pool of...

Keyword:

Bioengineering, Transcription factor, Synthetic biology, Promoter engineering, Protein engineering, and Metabolic engineering

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Andrew Younger

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/18/2018

Date Modified:

04/18/2018

Date Created:

2017-01-01

Resource Type:

Dissertation
Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Description:

The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...

Keyword:

Transcription factor, HMGN, Histone H1, Chromatin, STAT5, and Prolactin

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Suzanne Marie Schauwecker

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/18/2018

Date Modified:

04/18/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Development of a Generalizable Strategy for Converting Metabolite Binding Proteins into Metabolite Responsive Transcription Factors

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

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