Northwestern University

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Filtering by: Type Work Keyword deep brain stimulation

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Regulation of autonomous pacemaking and high frequency firing in the basal ganglia

Description:

Following dopaminergic denervation in Parkinson's Disease, firing patterns in several basal ganglia neuron populations are pathologically altered. In the globus pallidus (GP), this manifests as a loss of autonomous, rhythmic, high-frequency pacemaking and an appearance of correlated, oscillatory bursting. This oscillatory bursting is best disrupted through high-frequency stimulation of affected...

Keyword:

Parkinson's Disease, sodium channels, globus pallidus, pacemaking, deep brain stimulation, and basal ganglia

Subject:

Neuroscience Institute Graduate Program

Creator:

Jeff Mercer

Owner:

Scholarly Digital Publishing

Date Uploaded:

05/10/2018

Date Modified:

05/10/2018

Date Created:

2006-12-19

Resource Type:

Dissertation