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Description:: It is pertinent now more than ever that we find sustainable alternatives to produce chemicals. For decades, scientists and engineers have turned to biological systems to help meet societal needs in energy, medicine, materials, and moreespecially when chemical synthesis is untenable. Often, biologically-produced small molecules are insufficient for production at...
Keyword:: metabolic engineering, biotechnology, cell-free systems, biosynthetic pathway, synthetic biology, and enzymatic reactions
Subject:: Chemical and Biological Engineering
Creator:: Ashty Karim
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/14/2019
Date Modified:: 11/20/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: Metabolic engineering of microorganisms to produce useful compounds from renewable substrates is a promising means for sustainable, on-demand production of chemicals. However, efforts to design and engineer microbial cell factories are constrained by costly and slow “build” times in which each genetic variation requires re-engineering a new strain for each...
Keyword:: metabolic engineering, cell-free, synthetic biology, prototyping, and limonene
Subject:: Chemical and Biological Engineering
Creator:: Quentin Merle Dudley
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/25/2019
Date Modified:: 01/30/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: To increase the butanol titers and selectivity in Clostridium acetobutylicum we replaced the promoter of the alcohol/aldehyde dehydrogenase (aad) gene with the phosphotranbutyrylase (ptb) promoter and combined this with CoAT downregulation to minimize acetone production. This led to early production of high alcohol (butanol plus ethanol) titers and overall solvent...
Keyword:: metabolic engineering and Clostridium acetobutylicum
Subject:: Chemical and Biological Engineering
Creator:: William Sillers
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-04
Resource Type:: Dissertation

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