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Active Integration of Movement Related Synaptic Inputs by Spinal Motoneurons

Description:

During movement, the dendrites of spinal motoneurons receive steady excitatory and inhibitory synaptic input from supraspinal sources, interneurons, and sensory afferents. Motoneurons also have dendritic voltage sensitive ion channels. Most notable is a persistent inward current (PIC), which can enhance the amplitude of synaptic input by several fold. PICs are...

Keyword:

persistent inward currents, active dendrites;spinal motoneurons, and sensorimotor integration

Subject:

Neuroscience Institute Graduate Program

Creator:

Allison Suzanne Hyngstrom

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/30/2018

Date Modified:

08/30/2018

Date Created:

2007-10-15

Resource Type:

Dissertation
Alterations of electrical properties in the adult motoneurons in the mSOD1 mouse model of Amyotrophic Lateral Sclerosis

Description:

In Amyotrophic Lateral Sclerosis (ALS), spinal motoneurons degenerate in the order of large motoneurons that innervate fast and fatigable muscle fibers to small motoneurons that innervate slow muscle fibers (Pun et al. 2006). This order of degeneration is peculiar in that it is in direct opposition to the normal order...

Keyword:

motoneurons, persistent inward currents, animal model, neurodegeneration, Amyotrophic lateral sclerosis, and electrophysiology

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Seoan Huh

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/16/2018

Date Modified:

04/16/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Active Integration of Movement Related Synaptic Inputs by Spinal Motoneurons

Alterations of electrical properties in the adult motoneurons in the mSOD1 mouse model of Amyotrophic Lateral Sclerosis

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