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Description:: Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
Keyword:: induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction
Subject:: Molecular biology and Neurosciences
Creator:: Stojkovska, Iva
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793

Description:: Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
Keyword:: [SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1
Subject:: Molecular biology, Bioinformatics, and Neurosciences
Creator:: Goncharoff, Dustin Kenneth
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538

Description:: Saccharomyces cerevisiae contains several epigenetic elements known as yeast prions. Our laboratory discovered the yeast prion [SWI+], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. Formation of [SWI+] results in abolishment of multicellular features and a partial loss-of-function phenotype of non-glucose carbon source usage. Our laboratory...
Keyword:: amyloids, protein aggregation, prion, Saccharomyces cerevisiae, Swi1, and prion domain
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Stephanie Valtierra
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/26/2018
Date Modified:: 10/26/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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