We rely on the properties of our skeletal muscles to traverse our world, interact with objects, and complete everyday tasks. The macroscopic properties of muscles that endow us with these abilities arise from the material properties of muscle fibers and the surrounding extracellular matrix (ECM), as well as how they...
The integration of field-programmable gate arrays (FPGAs) into large scale computing systems is gaining attention. In these systems, real-time data handling for networking, tasks for scientific computing, and machine learning can be executed with customized datapaths on reconfigurable fabric within heterogeneous compute nodes. At the same time, high-level synthesis (HLS)...
Multistage optimization is a prominent modeling tool to solve a broad range of dynamic decision-making problems in the presence of uncertainty. However, computing optimal policies is intractable, since they are obtained by considering all possible realizations of uncertainties and subsequent future decisions over time. To overcome these challenges, we present...
Chemical modifications of oligonucleotides (ONs) have advanced these molecules towards clinical approvals. On their own, native ONs have poor pharmacokinetic properties, such as rapid degradation by nucleases and poor cell uptake, which limit their potential therapeutic applications. Chemical modifications of ONs can increase their stability, alter their interactions with cells,...
The development of new catalytic methodologies for the precision synthesis of carbon-carbon bonds is central to the advancement of synthetic organic chemistry. Significant focuses of these efforts are made on the enantio- and diastereoselective synthesis of carbon frameworks, especially as chemists and biologists become more aware of the impact of...
After spending most of her flight back to Ghana writing a letter to her estranged lover, Sissie, Ama Ata Aidoo’s protagonist in Our Sister Killjoy, observes the actions of her fellow passengers and reads the atmosphere onboard the airplane as that of “another human market-place.” Sissie’s statement transports into her...
We study the symmetry groups with respect to various equivalence relations defined on subshifts, and more generally, on Cantor systems. Two basic notions of equivalence for dynamical systems are conjugacy and flow equivalence. In this dissertation, we focus on the well-studied automorphism group, which is the group of self-conjugacies, and...
We present two ways in which measures of information can be used for the design and analysis of neural networks in both the brain and the computer. In the brain, stimulus is often represented as a distributed pattern of activity in a network of neurons. The quality of such population...
This dissertation argues that royal nomadism, the custom whereby medieval rulers moved between many castles in a predetermined cycle, fundamentally affected the floorplan, use, and adornment of courtly built environments. This argument is a new departure for the study of castles. Scholars of medieval castles acknowledge that rulers passed through...
Proper spatiotemporal expression of genes is essential during development. One method of regulation of signaling-responsive genes is at the level of transcription. In this work, I present the adaptation of single molecule fluorescent in situ hybridization for use in Drosophila imaginal disc tissues in order to more precisely quantify transcript...