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-
- Description:
- Androgen receptor pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance is common. Here, we used a CRISPR activation screen to identify genes that promote enzalutamide resistance in the metastatic castration-sensitive prostate cancer cell line LNCaP. We found that activation of the TGF-β target gene, PRRX2, promoted...
- Subject:
- Biology
- Creator:
- Rodriguez, Yara
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16015 and etdadmin_upload_898469
-
- Description:
- Cells are complex, autonomous machines that integrate many environmental cues to execute a desired response. Though this property makes cells versatile, it presents significant design challenges when, to treat diseases, we must alter cellular responses. To understand changes to the complex regulatory pathways that cause diseases, studies often investigate the...
- Keyword:
- systems biology, machine learning, dynamics, regulation, and differential gene expression
- Subject:
- Bioinformatics and Biology
- Creator:
- Finkle, Justin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14568 and etdadmin_upload_656753
-
- Description:
- Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
- Keyword:
- Reactive oxygen species, Cancer, Mitochondria, and Metabolism
- Subject:
- Biology, Health sciences, and Medicine
- Creator:
- Kong, Hyewon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362
-
- Description:
- Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
- Keyword:
- emergence, compound eye, self organization, Drosophila, morphogenesis, and pattern formation
- Subject:
- Biology, Biophysics, and Developmental biology
- Creator:
- Gallagher, Kevin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16245 and etdadmin_upload_928342
-
- Description:
- Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity...
- Keyword:
- Movement Disorder, Spinal Cord Injury, and Serotonin
- Subject:
- Physiology, Biology, and Neurosciences
- Creator:
- Shelton, Owen Adio
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16444 and etdadmin_upload_970159
-
- Description:
- Neurodegenerative diseases (NDs) commonly involve the accumulation and aggregation of neurotoxic proteins that impair and ultimately destroy specific neurons. Considerable evidence from human and animal studies indicates that many NDs show disrupted circadian and sleep as symptoms. Yet little is known about the molecular mechanisms by which genes cause NDs...
- Keyword:
- genetic screen, neurodegeneration, Huntington’s disease, and circadian
- Subject:
- Biology and Neurosciences
- Creator:
- Xu, Fangke
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14655 and etdadmin_upload_662687
-
- Description:
- Spinal cord injury (SCI) is a devastating injury, which can be caused by motor vehicle accidents, violence, and non-traumatic causes. These injuries can leave patients with lifelong paralysis, as well as incontinence and life threatening autonomic dysreflexia. There is currently no FDA approved treatment for SCI. Spinal injury disrupts the...
- Keyword:
- Nanotechnology, Fibronectin, Spinal Cord Injury, Fibrosis, Mechanical Properties, and Gliosis
- Subject:
- Biology, Biomechanics, and Neurosciences
- Creator:
- Cooper, John Gregory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14557 and etdadmin_upload_650745
-
- Description:
- Prostate cancer (PCa) is the second most common cancer in American men and has led to approximately 29K deaths in 2018. The androgen signaling pathway plays a pivotal role in the pathogenesis of PCa, and androgen deprivation therapy (ADT) has been the main therapeutic approach for PCa. However, almost all...
- Keyword:
- lysine methylation, FOXA1 methylation, WD40 motif protein, FOXA1 ubiquitination, ChIP-seq, and polycomb repressive complex 2
- Subject:
- Biology
- Creator:
- Park, Su Hong
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15433 and etdadmin_upload_787083
-
- Description:
- The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal, currently available treatment strategies often leave patients with disfiguring scars on their faces, heads, and necks. Moreover, the high recurrence rates of BCC...
- Keyword:
- zinc finger transcription factors, 3D skin cancer model, Basal Cell Carcinoma, Gli transcription factors, cobalt-Schiff base, and graphene oxide
- Subject:
- Inorganic chemistry, Biology, and Biochemistry
- Creator:
- Dukes, Meghan Ward
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_923011 and http://dissertations.umi.com/northwestern:16188
-
- Description:
- One of the fundamental observations in oncology is that the rate of cancer malignancy increases with age, which applies to most human malignancies including breast cancer. Therefore, it is crucial to elucidate the mechanistic connection between aging and carcinogenesis. The NAD+-dependent sirtuin family, specifically SIRT3, the primary mitochondrial deacetylase, which...
- Keyword:
- MnSOD, mitochondria, Sirtuin, cancer, ACSS1, and metabolism
- Subject:
- Biology
- Creator:
- Gao, Yucheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15526 and etdadmin_upload_815100
-
- Description:
- The BCR-ABL negative Myeloproliferative Neoplasms (MPNs) are clonal hematopoietic stem-cell disorders characterized by abnormal proliferation of differentiated myeloid lineages. MPNs include 3 clinically distinct disorders: Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). 95% of MPNs are characterized by driver mutations in Janus Kinase 2 (JAK2), Thrombopoietin receptor...
- Keyword:
- STK11, AML, Megakaryocytes, Reactive Oxygen Species, Leukemia, and MPN
- Subject:
- Biology and Medicine
- Creator:
- Marinaccio, Christian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15470 and etdadmin_upload_796403
-
- Description:
- This thesis proposes a robust multi-pronged approach to study the effect of nanoparticles on cells. In the first place, this work is focused on investigation of the protein corona that accumulates on the surface of nanoparticles internalized by the cells and their poly-pathway effects on protein availability and messenger RNA...
- Keyword:
- PARP, Nanoparticles, BIRC5, XFM, and SR-FTIR
- Subject:
- Nanotechnology, Biology, and Biochemistry
- Creator:
- Lastra, Ruben Omar
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_837951 and http://dissertations.umi.com/northwestern:15671
-
- Description:
- The planarian flatworm Schmidtea mediterranea is capable of recovery from nearly any injury, including regenerating an entire brain after decapitation, made possible by a pool of pluripotent stem cells which maintain all of the worm’s tissues into adulthood. However, the signals that control the production of new neurons in these...
- Keyword:
- Neurogenesis, Planaria, Regeneration, Stem cells, and Tec Kinase
- Subject:
- Biology
- Creator:
- Karge, Alexander
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15021 and etdadmin_upload_720401
-
- Description:
- The negative early and late health consequences from exposure to artificial sources of radiation are particularly apparent in victims of radiological emergencies who were diagnosed with cancer, radiation pneumonitis, among other conditions. The renaissance of nuclear energy, increased use of ionizing radiation in the medical field, and nuclear threats from...
- Keyword:
- Radiobiology, Ionizing Radiation, Radionuclides, and Radiation Biology
- Subject:
- Epidemiology, Biology, and Health sciences
- Creator:
- Copeland-Hardin, Letonia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16738 and etdadmin_upload_1013192
-
- Description:
- The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
- Keyword:
- calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
- Subject:
- Biology, Cellular biology, and Developmental biology
- Creator:
- Romero Tejeda, Marisol
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446