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Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

Description:

Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...

Keyword:

Development, Gene Regulation , Gene Expression, and Metabolism

Subject:

Developmental Biology

Creator:

Bagheri Lab, Carthew Lab, and Amaral Lab

Owner:

Sebastian Bernasek

Language:

English

Date Uploaded:

01/24/2019

Date Modified:

11/03/2020

Date Created:

2019-01-24

Resource Type:

Dataset
The TRIP8b-HCN Interaction as a Therapeutic Target

Description:

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the heart and central nervous system where they regulate membrane excitability. Recently, inhibiting HCN channels in the hippocampus has been identified as a possible therapeutic intervention for the treatment of Major Depressive Disorder (MDD). However, based on the high expression level of...

Keyword:

HCN, OPC, Oligodendrocyte, TRIP8b, and Depression

Subject:

Neuroscience, Biochemistry, and Developmental Biology

Creator:

Kyle Andrew Lyman

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/17/2019

Date Modified:

06/17/2019

Date Created:

2016-01-01

Resource Type:

Dissertation

Alternate Identifier:

https://doi.org/10.21985/N2W781

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Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

The TRIP8b-HCN Interaction as a Therapeutic Target

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