Index Catalog // Arch : Northwestern University Institutional Repository

Description:: There is increasing evidence that links chronic activation of glial cells and the subsequent self-propagating cycle of neuroinflammation to the neurodegenerative progression of Alzheimer's disease (AD). Nevertheless, attempts to identify currently approved drugs capable of safely attenuating the neuroinflammatory processes in AD have proven disappointing to date, and the development...
Keyword:: neuroinflammation, beta-amyloid, glia, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jeffrey Michael Craft
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/10/2018
Date Modified:: 05/10/2018
Date Created:: 2007-03-05
Resource Type:: Dissertation

Description:: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
Keyword:: MFG-E8, phagocytosis, apoptosis, Gas6, Alzheimer's disease, and microglia
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Abby Denise Fuller
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/14/2018
Date Modified:: 09/14/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

Description:: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
Keyword:: translation, energy metabolism, BACE1, amyloid, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tracy O'Connor
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-04
Resource Type:: Dissertation

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