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  1. Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

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    Description: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
    Keyword: amyloid, energy metabolism, BACE1, Alzheimer's disease, and translation
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Tracy O'Connor
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/20/2018
    Date Modified: 09/20/2018
    Date Created: 2008-12-04
    Rights: In Copyright
    Resource Type: Dissertation
  2. The modulation of MFG-E8 mediated microglial phagocytosis

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    Description: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
    Keyword: phagocytosis, MFG-E8, apoptosis, Alzheimer's disease, Gas6, and microglia
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Abby Denise Fuller
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-08-11
    Rights: In Copyright
    Resource Type: Dissertation
  3. The N-Terminus of Tau in Filament Formation and the Regulation of Axonal Transport: A Perspective on Tau Assembly and Toxicity

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    Description: In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...
    Keyword: kinesin, filament, axonal transport, tau, and Alzheimer's disease
    Subject: Neuroscience Institute Graduate Program
    Creator: Nichole LaPointe
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/06/2018
    Date Modified: 09/06/2018
    Date Created: 2008-02-21
    Rights: In Copyright
    Resource Type: Dissertation
  4. Neuroinflammation in an Alzheimer's Disease Animal Model and the Effectiveness of Selective Suppression of Glial Activation

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    Description: There is increasing evidence that links chronic activation of glial cells and the subsequent self-propagating cycle of neuroinflammation to the neurodegenerative progression of Alzheimer's disease (AD). Nevertheless, attempts to identify currently approved drugs capable of safely attenuating the neuroinflammatory processes in AD have proven disappointing to date, and the development...
    Keyword: neuroinflammation, glia, beta-amyloid, and Alzheimer's disease
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Jeffrey Michael Craft
    Owner: Scholarly Digital Publishing
    Date Uploaded: 05/10/2018
    Date Modified: 05/10/2018
    Date Created: 2007-03-05
    Rights: In Copyright
    Resource Type: Dissertation
  5. The Role of the N-terminus of Tau in Alzheimer's Disease

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    Description: The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
    Keyword: tangle, frontotemporal dementia, tau, Alzheimer's disease, and N-terminus
    Subject: Neuroscience Institute Graduate Program
    Creator: Peleg Moshe Horowitz
    Owner: Scholarly Digital Publishing
    Date Uploaded: 05/07/2018
    Date Modified: 05/07/2018
    Date Created: 2006-11-16
    Rights: In Copyright
    Resource Type: Dissertation
  6. Hippocampal Subfield Deformity Patterns and Memory Function in Non-semantic Primary Progressive Aphasia and Amnestic Dementia of the Alzheimer Type

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    Description: Patients with the Primary Progressive Aphasia (PPA) clinical syndrome have diverse forms of neuropathology, one of which is the cellular and molecular abnormalities of Alzheimer’s disease (AD), at post mortem autopsy. Structural anatomical differences might aid in ante mortem differential diagnosis of neuropathology. The studies in this dissertation investigated one...
    Keyword: Hippocampus, Structural MRI, Alzheimer's disease, Neuropsychology,, Memory, and Primary Progressive Aphasia
    Subject: Clinical Psychology
    Creator: Adam Christensen
    Owner: Scholarly Digital Publishing
    Date Uploaded: 02/19/2018
    Date Modified: 02/19/2018
    Date Created: 2016-01-01
    Rights: In Copyright
    Resource Type: Dissertation