Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Proper size control of organs and tissues is critical to their function, and it is necessary for the millions of precisely sized tubes that make up those organs— for example, excessive cell growth can lead to devastating diseases such as Polycystic Kidney Disease. The regulation of tube growth is therefore...
Keyword:: Trafficking, Non-apoptotic, Trachea, Caspase, and Apoptosis
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: McSharry, Saoirse Susan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_661142 and http://dissertations.umi.com/northwestern:14599

Description:: Eosinophils are major effector cells in diseases including asthma, rhinitis, certain gastrointestinal disorders and atopic dermatitis. Current treatments include mediator antagonists and anti-inflammatory drugs that reduce allergic cell numbers and inhibit mediator release, but they are not fully effective or curative. On their surface, eosinophils selectively express Siglec-8 (sialic acid-binding...
Keyword:: Siglec-8, Eosinophils, Apoptosis, and Signaling
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Daniela Janevska Carroll
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/23/2019
Date Modified:: 01/30/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. While there are numerous endogenous Bcl-2 antagonists that share similar homology, structure, topology, and expression pattern, only the loss of Bim in mice is sufficient to lead to the development of a systemic autoimmunity. Even loss of both...
Keyword:: Apoptosis
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: FuNien Tsai
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/23/2019
Date Modified:: 01/23/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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