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  1. The Regulation of Infection-Induced Cardiac Autoimmunity and Natural Dissemination of Trypanosoma cruzi in Experimental Chagas Heart Disease

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    Description: Chagas heart disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is still regarded as a major public health problem in Central and South America. The finding of cardiac specific autoimmunity during infection in both humans and experimental animals has provided a basis for investigation of its potential role...
    Keyword: Myosin, Cardiac, Trypanosoma cruzi, Luminescence, Chagas, and Autoimmunity
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Kenneth Vincent Hyland
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-11-10
    Rights: In Copyright
    Resource Type: Dissertation
  2. Dual Mechanisms for Antigen-Specific Peripheral Tolerance Induction as a Therapy for Experimental Autoimmune Encephalomyelitis

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    Description: MHC class II-restricted T cell responses are a common driving force of autoimmune disease. Numerous therapeutic strategies target CD4+ T cells hoping to attenuate autoimmune responses and restore self-tolerance. We have previously reported that i.v. treatment with antigen-pulsed, ethylenecarbodiimide (ECDI)-fixed splenocytes (Ag-SP) is an efficient protocol to induce Ag-specific tolerance...
    Keyword: Multiple Sclerosis, Autoimmunity, T cell, Experimental Autoimmune Encephalomyelitis, and Tolerance
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Danielle Marie Turley
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/28/2018
    Date Modified: 08/28/2018
    Date Created: 2007-12-07
    Rights: In Copyright
    Resource Type: Dissertation