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Filtering by: Keyword BH3 Keyword HER-2/neu Resource type Dissertation Subject Integrated Graduate Program in the Life Sciences

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1. Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

Description:: Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
Keyword:: HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Anne Marie Strohecker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 07/30/2018
Date Modified:: 07/30/2018
Date Created:: 05-15-2007
Resource Type:: Dissertation