Index Catalog // Arch : Northwestern University Institutional Repository

Regulation of FucT-VII expression in CD4-positive T cells

Description:: CD4-positive T cells express ligands for E- and P-selectins, carbohydrate-binding adhesion molecules that are induced on inflamed endothelium. The interaction between selectins and the selectin ligands facilitates the migration of T cells to sites of inflammation. The fucosyltransferase FucT-VII is essential for selectin ligand formation but the signaling and transcriptional...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Dimitrios G. Zisoulis
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/09/2018
Date Modified:: 05/09/2018
Date Created:: 2006-12-11
Resource Type:: Dissertation

Molecular mechanisms mediating activation of cytomegalovirus major immediate early enhancer in allogeneic transplantation

Description:: Reactivation of latent human cytomegalovirus is of significant concern in immunocompromised transplant patients. However, the mechanisms controlling reactivation of latent CMV have not been understood. It is likely that reactivation is initiated by induction of IE gene expression. In this thesis, I studied molecular mechanisms leading to transcriptional activation of...
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Soo Jung Kim
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/10/2018
Date Modified:: 05/10/2018
Date Created:: 2006-12-22
Resource Type:: Dissertation

The Role Of The mTOR Pathway In Mediating The Biological Effects Of Arsenic Trioxide

Description:: Arsenic trioxide (As203) is an arsenic-derivative that exhibits potent growth inhibitory effects against malignant cells. The remarkable antitumor effects of As203 in vitro and in vivo have prompted the development of various clinical trials that established its activity in acute promyelocytic leukemia (APL). As203 is part of the standard treatment...
Keyword:: Biology, Cell, and Health Sciences
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Patrick Jang Yoon
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/21/2018
Date Modified:: 05/21/2018
Date Created:: 2007-03-12
Resource Type:: Dissertation

Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

Description:: Most women diagnosed with epithelial ovarian carcinoma (EOC) initially present with metastases, but little is known about the regulation of ovarian tumor cell dissemination by the tumor microenvironment. Because ovarian cancer cell dissemination is mostly limited to the peritoneal cavity and often results in the accumulation of malignant ascites, the...
Keyword:: Biology and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jaime Symowicz
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/21/2018
Date Modified:: 05/21/2018
Date Created:: 2007-03-12
Resource Type:: Dissertation

Mechanisms of Bladder Barrier Dysfunction during Neurogenic Cystitis: the Role of TNF and Mast Cells

Description:: The primary function of the human urinary bladder is to store urine, while maintaining a permeability barrier that protects underlying tissues from noxious urinary components. Inflammatory diseases of the bladder, including urinary tract infection (UTI) and interstitial cystitis (IC), afflict millions of patients in the US annually and cause significant...
Keyword:: Physiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Michael C Chen
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/30/2018
Date Modified:: 05/30/2018
Date Created:: 2007-05-11
Resource Type:: Dissertation

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Description:: Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jasmina Omerovic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Understanding the mechanism of protein processing by the proteasome

Description:: The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
Keyword:: Chemistry, Biology, and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tian Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

TGF-beta and caner development: the role of TGF-beta in converting CD4+CD25- T cells into CD4+CD25+ T regulatroy cells and a TbRIIDN-tk/Ganciclovir suicide system in cancer gene therapy

Description:: Initial studies described the ability of CD4+CD25+ T regulatory (Treg) cells in suppressing autoimmune diseases in animal models. An emerging interest has focused on the potential role of Treg cells in cancer development and progression as they have been shown to suppress anti-tumor immunity. In the present study, CD4+CD25- T...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Victoria Chunyan Liu
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/26/2018
Date Modified:: 06/26/2018
Date Created:: 2007-05-15
Resource Type:: Dissertation

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

Description:: The response to reduced levels of oxygen (hypoxia) is essential for embryonic development by promoting the proper formation of vascular networks. Conversely, hypoxia also promotes the development of pathophysiological processes such as pulmonary hypertension and cancer. The main mediator of responses to hypoxia within the cell is the transcription factor...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Eric Bell
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/01/2018
Date Modified:: 08/01/2018
Date Created:: 07-27-2007
Resource Type:: Dissertation

Inhibition of Caspases by the Small Heat Shock Protein, HspB2

Description:: HspB2 was discovered as a chaperone of muscular dystrophy protein kinase (DMPK) and originally named, DMPK binding protein (MKBP) and presently called HspB2. Functionally, MKBP binds to DMPK and stabilizes its kinase activity, thereby accelerating the progression of muscular dystrophy. Although other binding partners of HspB2 have been found, the...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Shayna Oshita
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-08-28
Resource Type:: Dissertation

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Regulation of FucT-VII expression in CD4-positive T cells

Molecular mechanisms mediating activation of cytomegalovirus major immediate early enhancer in allogeneic transplantation

The Role Of The mTOR Pathway In Mediating The Biological Effects Of Arsenic Trioxide

Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

Mechanisms of Bladder Barrier Dysfunction during Neurogenic Cystitis: the Role of TNF and Mast Cells

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Understanding the mechanism of protein processing by the proteasome

TGF-beta and caner development: the role of TGF-beta in converting CD4+CD25- T cells into CD4+CD25+ T regulatroy cells and a TbRIIDN-tk/Ganciclovir suicide system in cancer gene therapy

Mechanisms of Oxygen Sensing and Hypoxic Increase in Replicative Lifespan

Inhibition of Caspases by the Small Heat Shock Protein, HspB2

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