Index Catalog // Arch : Northwestern University Institutional Repository

Mechanisms Underlying Chemokine Signaling-Mediated Hypersensitization of Primary Sensory Neurons in Association with Neuropathic Pain

Description:: Pain normally subserves a vital role in the survival of the organism by prompting the avoidance of situations associated with tissue damage. However, the sensation of pain can become dissociated from its normal physiological role when the pain-sensing nervous system becomes hypersensitive, a condition known as neuropathic pain. Currently available...
Keyword:: Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Hosung Jung
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

The Behavioral and Neural Basis for the facilitation of Insight Problem-Solving by a Positive Mood

Description:: Previous research has shown that creative insight problem-solving is distinct from systematic analytical problem-solving. Behaviorally, a positive mood has shown to facilitate insights but without knowing the processes that are fundamental to insight, the mechanisms as to how a positive mood facilitates insights have remained unspecified. Here, we investigate the...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Karuna Subramaniam
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

Mechanisms regulating astrogliosis and functional recovery following spinal cord injury

Description:: The studies in this thesis are directed towards defining the signaling mechanisms that regulate astrogliosis after SCI and towards developing potential therapeutic techniques for modifying this process. The central hypothesis is that alteration of the extracellular milieu after SCI can limit the deleterious effects of glial scar formation and enhance...
Keyword:: Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Vibhu Vinodchandra Sahni
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/19/2018
Date Modified:: 09/19/2018
Date Created:: 2008-11-25
Resource Type:: Dissertation

Synaptic transmission and plasticity in cerebellar nuclear neurons

Description:: Synapses in the central nervous system vary widely in how they transmit and store information. The properties of short-term and long-term plasticity, in particular, seem to be specific for each class of synapse studied. The types of plasticity expressed at a particular synapse determine how it processes, transmits and possibly...
Keyword:: Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Jason Pugh
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/10/2018
Date Modified:: 09/10/2018
Date Created:: 2008-05-06
Resource Type:: Dissertation

Trafficking mechanism of H channels in CA1 pyramidal neurons and its implication in the pathophysiology of temporal lobe epilepsy

Description:: Many ion channels are localized in specific subcellular domain of the neurons, and the proper localization is critical for the function of ion channels. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are asymmetrically distributed in the CA1 pyramidal neurons, enriched in the distal apical dendrites. H current, generated by h...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Minyoung Shin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

The Actin-Based Motility Machinery of Neuronal Growth Cone Veils.

Description:: The growth cone is a highly specialized motile structure with a distinctive and dynamically variable morphology. Current understanding of actin-based protrusive motility has been formulated in terms of the dendritic nucleation/array treadmilling model for lamellipodial protrusion and the convergent-elongation model for filopodial protrusion, that were based upon results obtained primarily...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Anne Katherine Mongju
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-07-30
Resource Type:: Dissertation

Mechanisms Underlying Response Suppression in Cat Visual Cortex

Description:: A comprehensive understanding of how image processing occurs in the primary visual cortex (V1) requires learning what aspects of neuronal responses are driven by strong feed-forward input from the lateral geniculate nucleus (LGN), and what aspects arise due to the densely recurrent network operating within the cortex itself. From an...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Ian Micah Finn
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-10-22
Resource Type:: Dissertation

Studies of the Homeostatic and Metabolic Regulation of GnRH Pulse Generator

Description:: Gonadotropin releasing hormone (GnRH) neurons comprise the final pathway through which the central nervous system exerts its control over the hypothalamic-pituitary-gonadal (HPG) axis. GnRH is released in a pulsatile manner, and conveyed to the anterior pituitary gland to stimulate synthesis and secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Wenyu Huang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/06/2018
Date Modified:: 08/06/2018
Date Created:: 2007-06-21
Resource Type:: Dissertation

Validating Dissociations between Human Memory Subtypes: Conceptual Priming, Familiarity, and Recollection

Description:: A comprehensive understanding of human memory requires both cognitive and neural descriptions of memory processes along with a conception of how memory processing drives behavioral responses and subjective experiences. Noninvasive neuroimaging techniques have greatly extended our understanding of the functional characteristics of human memory, and how neural events give rise...
Keyword:: Neuroscience and Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Joel Lawrence Voss
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-11
Resource Type:: Dissertation

Motivational Incentives Enhance Top-Down Modulation of Visual Spatial Attention in Healthy Aging and Mild Cognitive Impairment but not Probable Alzheimer's Disease

Description:: The goal of this dissertation was to examine the influence of motivational incentives on visual spatial attention in patients with probable Alzheimer's Disease (PRAD), patients with mild cognitive impairment (MCI) and healthy age-matched control subjects (EC). Specifically, I compared the ability of monetary incentives to influence behavioral and neural performance...
Keyword:: Biology
Subject:: Neuroscience Institute Graduate Program
Creator:: Lisa Bagurdes
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/22/2018
Date Modified:: 05/22/2018
Date Created:: 2007-05-03
Resource Type:: Dissertation

Properties of retinal ganglion cell receptive fields at the lower limit of visual sensitivity

Description:: The goal of this study was to investigate the properties of the retinal ganglion cell receptive field at low light levels. There has been considerable interest in whether the surround of a ganglion cell receptive field disappears and the center expands in size under scotopic conditions. The previous data from...
Keyword:: Biology and Resources
Subject:: Neuroscience Institute Graduate Program
Creator:: Jie Chen
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/22/2018
Date Modified:: 05/22/2018
Date Created:: 2007-04-25
Resource Type:: Dissertation

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Mechanisms Underlying Chemokine Signaling-Mediated Hypersensitization of Primary Sensory Neurons in Association with Neuropathic Pain

The Behavioral and Neural Basis for the facilitation of Insight Problem-Solving by a Positive Mood

Mechanisms regulating astrogliosis and functional recovery following spinal cord injury

Synaptic transmission and plasticity in cerebellar nuclear neurons

Trafficking mechanism of H channels in CA1 pyramidal neurons and its implication in the pathophysiology of temporal lobe epilepsy

The Actin-Based Motility Machinery of Neuronal Growth Cone Veils.

Mechanisms Underlying Response Suppression in Cat Visual Cortex

Studies of the Homeostatic and Metabolic Regulation of GnRH Pulse Generator

Validating Dissociations between Human Memory Subtypes: Conceptual Priming, Familiarity, and Recollection

Motivational Incentives Enhance Top-Down Modulation of Visual Spatial Attention in Healthy Aging and Mild Cognitive Impairment but not Probable Alzheimer's Disease

Properties of retinal ganglion cell receptive fields at the lower limit of visual sensitivity

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