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  1. Mechanisms regulating astrogliosis and functional recovery following spinal cord injury

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    Description: The studies in this thesis are directed towards defining the signaling mechanisms that regulate astrogliosis after SCI and towards developing potential therapeutic techniques for modifying this process. The central hypothesis is that alteration of the extracellular milieu after SCI can limit the deleterious effects of glial scar formation and enhance...
    Keyword: Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Vibhu Vinodchandra Sahni
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/19/2018
    Date Modified: 09/19/2018
    Date Created: 2008-11-25
    Rights: In Copyright
    Resource Type: Dissertation
  2. Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

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    Description: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
    Keyword: Molecular and Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Mark Rovedo
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/18/2018
    Date Modified: 09/18/2018
    Date Created: 2008-09-03
    Rights: In Copyright
    Resource Type: Dissertation
  3. Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

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    Description: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
    Keyword: Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Erick Lin
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/17/2018
    Date Modified: 09/17/2018
    Date Created: 2008-07-17
    Rights: In Copyright
    Resource Type: Dissertation
  4. Synaptic integration in excitable CA1 pyramidal neuron dendrites

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    Description: A pyramidal neuron receives thousands of inputs spread throughout its dendritic tree, which it must integrate into a decision about whether or not to fire action-potential output. Since action potentials are the primary means by which these neurons communicate with their network partners, understanding this input-output relationship is critical for...
    Keyword: Biology and Neuroscience
    Subject: Interdepartmental Biological Sciences Program
    Creator: Yael Katz
    Owner: Jason Christ Chandra
    Date Uploaded: 09/16/2018
    Date Modified: 09/16/2018
    Date Created: 2008-07-29
    Rights: In Copyright
    Resource Type: Dissertation
  5. Synaptic transmission and plasticity in cerebellar nuclear neurons

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    Description: Synapses in the central nervous system vary widely in how they transmit and store information. The properties of short-term and long-term plasticity, in particular, seem to be specific for each class of synapse studied. The types of plasticity expressed at a particular synapse determine how it processes, transmits and possibly...
    Keyword: Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Jason Pugh
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/10/2018
    Date Modified: 09/10/2018
    Date Created: 2008-05-06
    Rights: In Copyright
    Resource Type: Dissertation
  6. Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

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    Description: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
    Keyword: Biology and Microbiology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Maria Soderberg
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/06/2018
    Date Modified: 09/06/2018
    Date Created: 2008-03-25
    Rights: In Copyright
    Resource Type: Dissertation
  7. Analysis of the Requirement of Notch Signaling for EBV LMP2A Function in vitro and in vivo

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    Description: Epstein Barr Virus (EBV) is associated with malignancies of lymphoid and epithelial origin. While the precise role of EBV in oncogenesis remains elusive, latent membrane protein 2A (LMP2A) is detected in all EBV-associated malignancies, implicating LMP2A in their pathogenesis. Interestingly, LMP2A is expressed in EBV-associated malignancies such as Burkitt's Lymphoma,...
    Keyword: Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Leah J Anderson
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/31/2018
    Date Modified: 08/31/2018
    Date Created: 2008-03-31
    Rights: In Copyright
    Resource Type: Dissertation
  8. Trafficking mechanism of H channels in CA1 pyramidal neurons and its implication in the pathophysiology of temporal lobe epilepsy

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    Description: Many ion channels are localized in specific subcellular domain of the neurons, and the proper localization is critical for the function of ion channels. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are asymmetrically distributed in the CA1 pyramidal neurons, enriched in the distal apical dendrites. H current, generated by h...
    Keyword: Biology and Neuroscience
    Subject: Neuroscience Institute Graduate Program
    Creator: Minyoung Shin
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/27/2018
    Date Modified: 08/27/2018
    Date Created: 2007-12-07
    Rights: In Copyright
    Resource Type: Dissertation
  9. The Actin-Based Motility Machinery of Neuronal Growth Cone Veils.

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    Description: The growth cone is a highly specialized motile structure with a distinctive and dynamically variable morphology. Current understanding of actin-based protrusive motility has been formulated in terms of the dendritic nucleation/array treadmilling model for lamellipodial protrusion and the convergent-elongation model for filopodial protrusion, that were based upon results obtained primarily...
    Keyword: Neuroscience and Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Anne Katherine Mongju
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/27/2018
    Date Modified: 08/27/2018
    Date Created: 2007-07-30
    Rights: In Copyright
    Resource Type: Dissertation
  10. Inhibition of Caspases by the Small Heat Shock Protein, HspB2

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    Description: HspB2 was discovered as a chaperone of muscular dystrophy protein kinase (DMPK) and originally named, DMPK binding protein (MKBP) and presently called HspB2. Functionally, MKBP binds to DMPK and stabilizes its kinase activity, thereby accelerating the progression of muscular dystrophy. Although other binding partners of HspB2 have been found, the...
    Keyword: Biology and Molecular
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Shayna Oshita
    Owner: Scholarly Digital Publishing
    Date Uploaded: 08/27/2018
    Date Modified: 08/27/2018
    Date Created: 2007-08-28
    Rights: In Copyright
    Resource Type: Dissertation