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  1. Small RNA Structure and Dicer/Argonaute Dependence During RISC Assembly in Drosophila

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    Description: Short interfering RNAs (siRNAs) and microRNAs (miRNAs) are both processed from longer, double-stranded RNA (dsRNA) presursors by a member of the Dicer (Dcr) family of proteins. siRNAs generally arise from perfectly base-paired dsRNAs, whereas miRNAs are excised from 60-70 nt pre-miRNA hairpins containing multiple bulges and mismatches within the duplexed...
    Keyword: Biology
    Subject: Interdepartmental Biological Sciences Program
    Creator: Zhengying He
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/08/2018
    Date Modified: 10/08/2018
    Date Created: 2008-12-09
    Rights: In Copyright
    Resource Type: Dissertation
  2. Mechanisms Underlying Chemokine Signaling-Mediated Hypersensitization of Primary Sensory Neurons in Association with Neuropathic Pain

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    Description: Pain normally subserves a vital role in the survival of the organism by prompting the avoidance of situations associated with tissue damage. However, the sensation of pain can become dissociated from its normal physiological role when the pain-sensing nervous system becomes hypersensitive, a condition known as neuropathic pain. Currently available...
    Keyword: Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Hosung Jung
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/08/2018
    Date Modified: 10/08/2018
    Date Created: 2008-12-05
    Rights: In Copyright
    Resource Type: Dissertation
  3. The Behavioral and Neural Basis for the facilitation of Insight Problem-Solving by a Positive Mood

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    Description: Previous research has shown that creative insight problem-solving is distinct from systematic analytical problem-solving. Behaviorally, a positive mood has shown to facilitate insights but without knowing the processes that are fundamental to insight, the mechanisms as to how a positive mood facilitates insights have remained unspecified. Here, we investigate the...
    Keyword: Biology and Neuroscience
    Subject: Neuroscience Institute Graduate Program
    Creator: Karuna Subramaniam
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/02/2018
    Date Modified: 10/02/2018
    Date Created: 2008-12-05
    Rights: In Copyright
    Resource Type: Dissertation
  4. The Role of TGF-beta Variants in Breast Cancer

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    Description: TGF-β has been named the molecular Jekyll and Hyde of cancer due to its ability to both suppress and promote tumor development. Components of the TGF-β signaling pathway are often mutated in cancer to inhibit the tumor suppressor roles of TGF-β. Our lab studies how a 3-alanine deletion in the...
    Keyword: Genetics and Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Diana Susan Rosman
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/01/2018
    Date Modified: 10/01/2018
    Date Created: 2008-10-14
    Rights: In Copyright
    Resource Type: Dissertation
  5. Mechanisms regulating astrogliosis and functional recovery following spinal cord injury

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    Description: The studies in this thesis are directed towards defining the signaling mechanisms that regulate astrogliosis after SCI and towards developing potential therapeutic techniques for modifying this process. The central hypothesis is that alteration of the extracellular milieu after SCI can limit the deleterious effects of glial scar formation and enhance...
    Keyword: Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Vibhu Vinodchandra Sahni
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/19/2018
    Date Modified: 09/19/2018
    Date Created: 2008-11-25
    Rights: In Copyright
    Resource Type: Dissertation
  6. Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

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    Description: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
    Keyword: Biology and Molecular
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Mark Rovedo
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/18/2018
    Date Modified: 09/18/2018
    Date Created: 2008-09-03
    Rights: In Copyright
    Resource Type: Dissertation
  7. Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

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    Description: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
    Keyword: Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Erick Lin
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/17/2018
    Date Modified: 09/17/2018
    Date Created: 2008-07-17
    Rights: In Copyright
    Resource Type: Dissertation
  8. Synaptic integration in excitable CA1 pyramidal neuron dendrites

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    Description: A pyramidal neuron receives thousands of inputs spread throughout its dendritic tree, which it must integrate into a decision about whether or not to fire action-potential output. Since action potentials are the primary means by which these neurons communicate with their network partners, understanding this input-output relationship is critical for...
    Keyword: Biology and Neuroscience
    Subject: Interdepartmental Biological Sciences Program
    Creator: Yael Katz
    Owner: Jason Christ Chandra
    Date Uploaded: 09/16/2018
    Date Modified: 09/16/2018
    Date Created: 2008-07-29
    Rights: In Copyright
    Resource Type: Dissertation
  9. Synaptic transmission and plasticity in cerebellar nuclear neurons

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    Description: Synapses in the central nervous system vary widely in how they transmit and store information. The properties of short-term and long-term plasticity, in particular, seem to be specific for each class of synapse studied. The types of plasticity expressed at a particular synapse determine how it processes, transmits and possibly...
    Keyword: Biology
    Subject: Neuroscience Institute Graduate Program
    Creator: Jason Pugh
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/10/2018
    Date Modified: 09/10/2018
    Date Created: 2008-05-06
    Rights: In Copyright
    Resource Type: Dissertation
  10. Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

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    Description: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
    Keyword: Biology and Microbiology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Maria Soderberg
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/06/2018
    Date Modified: 09/06/2018
    Date Created: 2008-03-25
    Rights: In Copyright
    Resource Type: Dissertation