Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Chromatin is the biological material that packages our genetic information. In humans, 2 meters of linear DNA is compacted into an approximately 6 μm nucleus. Our DNA is transcribed into RNA, which is then translated into proteins. Cellular phenotype, the composite of all cellular functions, is defined by the entire...
Keyword:: Computational Modeling, Genomics, Chromatin, Nanoimaging, and Biophysics
Subject:: Biomedical engineering
Creator:: Virk, Ranya Kaur Aphrodite
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16197 and etdadmin_upload_924911

Description:: The purpose of my thesis research has been to understand the formation of mitotic chromosome structure by using chromosome micromanipulation. Folding mitotic chromosomes from their loose interphase form into their individualized, compacted form is required for easy handling of the chromosomes for cell division. This process is facilitated by several...
Keyword:: Mitosis, Histone PTMs, Chromosomes, SMC Complexes, Biophysics, and Meiosis
Subject:: Molecular biology and Biophysics
Creator:: Biggs, Ronald Joseph
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15852 and etdadmin_upload_862016

Description:: The overall goal of my thesis is to enhance our quantitative understanding of the biophysical properties of DNA a long polynucleotide chain, present in every living cell, that embodies the genetic information. The existence of DNA has been known to us for over a century, however, our understanding of its...
Keyword:: Biophysics
Subject:: Physics and Astronomy
Creator:: Sumitabha Brahmachari
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/28/2019
Date Modified:: 11/20/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: Eukaryotic gene transcription is a coordinated process involving the participation of a large number of proteins. Sequence-specific DNA-binding transcription factors function as activators or repressors of transcription and frequently recruit transcriptional coregulators that lack specific DNA-binding activity. These multi-protein complexes with intrinsic chromatin-modifying and chromatin-remodeling activities have emerged as key...
Keyword:: Biophysics
Subject:: Interdepartmental Biological Sciences Program
Creator:: Yuan He
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/07/2018
Date Modified:: 09/07/2018
Date Created:: 2008-05-07
Resource Type:: Dissertation

Description:: Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to chemical stimuli that can be either supplied externally or produced locally. Understanding of the fundamental mechanisms that govern angiogenesis suggests a powerful therapeutic approach that will allow to combat...
Keyword:: General and Biophysics
Subject:: Applied Mathematics
Creator:: Anna Tikhomirov
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/14/2018
Date Modified:: 08/14/2018
Date Created:: 2007-07-30
Resource Type:: Dissertation

Description:: One of the current goals in the biomaterials research is to develop implants with improved osteoconductivity and long-term stability. Thanks to its chemical similarity to the mineral phase of natural bone, hydroxyapatite (HA) has been extensively studied and clinically tested as a coating on metallic substrates, to obtain bioactive implants...
Keyword:: Biophysics
Subject:: Physics and Astronomy
Creator:: Zhendong Hong
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/07/2018
Date Modified:: 08/07/2018
Date Created:: 2007-09-05
Resource Type:: Dissertation

LIBRARIES | ARCH