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Description:: The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
Keyword:: APOE, Alzheimer, Stem Cells, and CRISPR
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Wadhwani, Anil R
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542

Description:: Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
Keyword:: Staphylococcus epidermidis, X-ray crystallography, Cryo-EM, Csm3, CRISPR, and Csm2
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Dorsey, Bryan William
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_655609 and http://dissertations.umi.com/northwestern:14567

Description:: DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
Keyword:: DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Chen, Siyu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936

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