Index Catalog // Arch : Northwestern University Institutional Repository

Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Description:: DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
Keyword:: DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Chen, Siyu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936

Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

Description:: Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
Keyword:: Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Murnan, Kevin Michael
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Description:: Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
Keyword:: Reactive oxygen species, Cancer, Mitochondria, and Metabolism
Subject:: Biology, Health sciences, and Medicine
Creator:: Kong, Hyewon
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362

microRNA Regulation of Genes with Genetic Variation and their Systems-Level Consequences in Cancer

Description:: Gene regulatory networks contain multiple components including microRNAs (miRNAs) that coordinate regulation of genes to produce higher level cell functions. miRNAs are small non-coding RNA molecules that modulate gene expression post-transcriptionally by binding to short target motifs on mRNA transcripts to down-regulate target genes. Because miRNA regulation of genes is...
Keyword:: Gene Regulation, Systems Biology, Single Nucleotide Polymorphisms, Pathways, Cancer, and microRNAs
Subject:: Chemical and Biological Engineering
Creator:: Gary Wilk
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/21/2019
Date Modified:: 10/21/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Description:: Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and...
Keyword:: Cancer
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jonathan Forrest Anker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/22/2019
Date Modified:: 04/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Toxicity Mediated by Seed-Dependent Off-Target Effects in RNA Interference

Description:: Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...
Keyword:: siRNA, RNA Interference, Cell Death, Cancer, shRNA, and DISE
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: William Edward Putzbach
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/01/2019
Date Modified:: 04/01/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

DNA Methylation in Repetitive Elements and Cancer

Description:: DNA methylation in repetitive elements (RE) suppresses their mobility and maintains genomic stability, and decreases in it are frequently observed in tumor and/or surrogate tissues. Averaging methylation across RE in the genome is widely used to quantify global methylation. Methylation of RE in humans is considered a surrogate for global...
Keyword:: Repetitive elements, Cancer, Machine learning, and DNA methylation
Subject:: Health Sciences Integrated PhD Program
Creator:: Yinan Zheng
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/26/2018
Date Modified:: 04/26/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Aberrant acetylation of mitochondrial proteins, due to loss of SIRT3, results in tumor permissive phenotypes and increases breast cancer malignancy risk

Description:: SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...
Keyword:: MnSOD, IDH2, Cancer, and Sirtuins
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Xianghui Zou
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/13/2018
Date Modified:: 04/13/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Development of Nanoparticle Conjugates for Diagnostic and Therapeutic Applications

Description:: Spherical Nucleic Acids (SNAs) are nanoparticle bioconjugates that have found use in a wide-range of diagnostic and therapeutic applications. These nanomaterials are composed from inorganic or organic core nanoparticle scaffolds that are functionalized with a dense surface layer of nucleic acids (typically DNA or RNA) that are oriented in a...
Keyword:: Diagnostic, Gold nanoparticle, Cancer, Bioassay, and Spherical Nucleic Acid
Subject:: Biomedical Engineering
Creator:: Alexander Scott
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/19/2018
Date Modified:: 02/19/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

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Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Defining and Therapeutically Targeting IDH1-WT Oncogenicity in GBM

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

microRNA Regulation of Genes with Genetic Variation and their Systems-Level Consequences in Cancer

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Toxicity Mediated by Seed-Dependent Off-Target Effects in RNA Interference

DNA Methylation in Repetitive Elements and Cancer

Aberrant acetylation of mitochondrial proteins, due to loss of SIRT3, results in tumor permissive phenotypes and increases breast cancer malignancy risk

Development of Nanoparticle Conjugates for Diagnostic and Therapeutic Applications

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