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Filtering by: Keyword Cell Cycle Subject Integrated Graduate Program in the Life Sciences

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Description:: Regulation of cell cycle and cell death are critical for normal cellular proliferation, tissue homeostasis, animal development, and the pathogenesis of human diseases such as cancer. Irregularities in cell cycle and cell death may result in tumorigenesis. In this dissertation, I describe my studies of a novel gene C53, which...
Keyword:: Mitosis, Cell Cycle, G2/M checkpoint, Cell Death, and C53
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Hai Jiang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/09/2018
Date Modified:: 05/09/2018
Date Created:: 2006-12-12
Resource Type:: Dissertation

Description:: It is critical to genomic integrity that DNA is replicated completely and faithfully during each cell cycle. The essential replication factor Cdt1 is a critical protein in preventing reinitiation of replication. Overexpression of Cdt1 causes re-replication in p53 null cells and transforms NIH3T3 cells, causing them to form tumors in...
Keyword:: Xenopus, Cell Cycle, Geminin, Cdt1, and Re-Replication
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Sarah Lynn Kerns
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/01/2018
Date Modified:: 06/01/2018
Date Created:: 2007-05-11
Resource Type:: Dissertation

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