Regulation of cell cycle and cell death are critical for normal cellular proliferation, tissue homeostasis, animal development, and the pathogenesis of human diseases such as cancer. Irregularities in cell cycle and cell death may result in tumorigenesis. In this dissertation, I describe my studies of a novel gene C53, which...
It is critical to genomic integrity that DNA is replicated completely and faithfully during each cell cycle. The essential replication factor Cdt1 is a critical protein in preventing reinitiation of replication. Overexpression of Cdt1 causes re-replication in p53 null cells and transforms NIH3T3 cells, causing them to form tumors in...