Northwestern University

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Determining Disease Mechanisms of PACS1 Syndrome ASD Using iPSC-Derived Models

Description:

Autism spectrum disorder (ASD) and intellectual disability (ID) are two of the most highly prevalent neurodevelopmental disorders (NDDs), each affecting roughly 2% of the population. Despite the need for therapies, few exist due to a myriad of challenges, such as the complex underlying genetic etiology and historic inaccessibility of neural...

Keyword:

PACS1 syndrome, Induced pluripotent stem cells, Single-cell RNA sequencing, Intellectual disability, Cerebral organoids, and Autism spectrum disorder

Subject:

Molecular biology and Neurosciences

Creator:

Rylaarsdam, Lauren Elizabeth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_984633 and http://dissertations.umi.com/northwestern:16538