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Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease

Description:

Desmoplakin (DP) is a component of desmosomes, critical adhesive complexes found in cardiac intercalated discs. DP is often mutated in arrhythmogenic cardiomyopathy (AC), an inherited disorder that is a frequent cause of sudden cardiac death. The disease progression of AC is characterized by cardiomyocyte cell death and replacement of the...

Keyword:

Desmosome, Desmoplakin, Rho, Arrhythmogenic, Connexin, and Cardiocutaneous

Creator:

Chen Yuan Kam

Owner:

Scholarly Digital Publishing

Date Uploaded:

11/19/2019

Date Modified:

11/19/2019

Date Created:

2018-01-01

Resource Type:

Dissertation
The Role of Desmoglein-1 in Epidermal Stratification via Retromer-mediated Recycling and Actin Regulation

Description:

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, desmogleins and desmocollins, are related to the classical cadherins but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The...

Keyword:

Keratinocyte, Desmosome, Retromer chaperone, Dsg1, SAM syndrome, and Endosomal trafficking

Subject:

Cellular biology

Creator:

Hegazy, Marihan

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_944940 and http://dissertations.umi.com/northwestern:16344

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Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease

The Role of Desmoglein-1 in Epidermal Stratification via Retromer-mediated Recycling and Actin Regulation

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