Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
Keyword:: Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
Subject:: Molecular biology, Gender studies, and Cellular biology
Creator:: Fischer, Julie Anne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216

Description:: The answer to the question “Why do we sleep?” lies in understanding the biological underpinnings of homeostatic drive to sleep. Wakefulness is correlated with numerous changes in brain activity, structure and gene/protein expression that re-normalize following sleep however which of these elements is sufficient to cause sleep drive and how...
Keyword:: Circadian, Homeostasis, Sleep, Drosophila, and Time
Subject:: Neurosciences
Creator:: Andreani-fabroni, Tomas Sergio
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_906530 and http://dissertations.umi.com/northwestern:16115

Description:: Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
Keyword:: emergence, compound eye, self organization, Drosophila, morphogenesis, and pattern formation
Subject:: Biology, Biophysics, and Developmental biology
Creator:: Gallagher, Kevin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16245 and etdadmin_upload_928342

Description:: The insulin/Insulin-Like Growth Factor (IGF) pathway is essential for linking nutritional status to growth and metabolism. MicroRNAs (miRNAs) are short RNAs that are players in the regulation of this process. The miRNA miR-7 shows highly conserved expression in insulin-producing cells across the animal kingdom. However, its conserved functions in regulation...
Keyword:: MicroRNA, Insulin, and Drosophila
Subject:: Molecular biology and Endocrinology
Creator:: Agbu, Pamela
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15272 and etdadmin_upload_764541

Description:: Cells are often precisely organized into patterns within developing tissues. This precision must emerge from biochemical processes within, and between cells, that are inherently stochastic. I investigated the impact of stochastic gene expression on self-organized pattern formation, focusing on Senseless (Sens), a key target of Wnt and Notch signaling during...
Keyword:: gene expression, microRNA, cell fate, Drosophila, self-organization, and noise
Subject:: Applied mathematics, Statistics, and Developmental biology
Creator:: Giri, Ritika
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_763812 and http://dissertations.umi.com/northwestern:15251

Description:: Organismal development depends upon countless cell decisions to adopt particular fates at the appropriate time and place. These decisions are executed by systems of biochemical reactions called regulatory networks. Elucidating the general principles underlying the structure and function of these networks is vital to understanding all developmental processes, as well...
Keyword:: Development, Quantitative Biology, Cell Decisions, Mosaic Analysis, Drosophila, and Metabolism
Subject:: Chemical engineering and Developmental biology
Creator:: Bernasek, Sebastian Michal
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_663067 and http://dissertations.umi.com/northwestern:14676

Description:: After nearly 100 years of research, the function of sleep is unknown, prompting the desire to examine its regulation in a simpler model organism. In 2000, <em>Drosophila</em> was described as a novel model system to investigate sleep. These early studies defined features of normal sleep in <em>Drosophila</em>, and presented evidence...
Keyword:: genetics, sleep, mushroom bodies, Clock, neuroanatomy, and Drosophila
Subject:: Neuroscience Institute Graduate Program
Creator:: Jena Pitman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-08-15
Resource Type:: Dissertation

LIBRARIES | ARCH