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Filtering by: Keyword FOXA1 Keyword Prostate cancer

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Perturbations of Epigenetic Events in Prostate Cancer: The Role of TET1, A DNA Demethylase

Description:

FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...

Keyword:

Prostate cancer, TET1, Epigenetics, and FOXA1

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Yeqing (Angela) Yang

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/26/2018

Date Modified:

01/29/2019

Date Created:

2017-01-01

Resource Type:

Dissertation